Expression And Significance Of Fascin In Bladder Cancer

ObjectiveTo observe the expression of Fascin in bladder cancer and bladder normal tissues, analyse its correlation with tumor grade, clinical stage, tumor size, and the expression of P53, Ki-67, MDR and CK20 of bladder cancer.MethodsA total of 111 patients with bladder cancer treated at the Department of Urology, The First Affiliated Hospital of China Medical University between September 2007 and July 2008 were included into the study. A significant amount of normal urothelia was present in 42 specimens of cancerous lesions. All specimens were fixed in 10% formalin, embedded in paraffin, and cut into 4μm serial sections. Immunohistoc-hemistry was used to observe the expression of Fascin, P53, Ki67, CK20, and MDR in 111 tissues of bladder cancer and 42 normal epithelial tissues. The relationship between the expression of Fascin and clinicopathlogical parameters, expression of P53, Ki67, CK20 and MDR were analysed stastically.ResultOverall, Non-Fascin expression was found in normal transitional epithelium.94 in 111 cases of bladder cancer specimens show positive Fascin expression. The expression of Fascin in normal and carcinoma tissues have difference (P＜0.001). The expression of Fascin is positively connected with clinical stage(P=0.001), tumor size(P=0.011), expression of Ki67(P=0.001), and has no connection with age, sex, tumor grade and the expression of P53, MDR, CK20 (P>0.05).ComclusionUpregulation of Fascin in bladder cancer might play an important role in its growth and invasion. It may be used as a prognostic marker and a new treatment target of bladder cancer.