Expression And Significance Of Smad2,Smad3 And β-catenin In Pathological Scar

ObjectiveThe expression of Smad3 of TGF-β/Smad pathway and P-catenin of Wnt/β-catenin pathway in pathological scar was studied, to make sure that the role of these pathways in the pathogenesis of pathological scar. It supplies theory basis of cytobiology, molecular biology and pathology for clinical preservation and treatment of scar.MethodsImmunohistochemiscal techuique was performed to detect the expression and distribution of Smad3 andβ-catenin in 30 cases of keloid(group A),30 cases of hypertrophic scar(group B) and 20 cases of normal skin(group C), and statistics was used to analyze the data to study the expression regularity of Smad3 andβ-catenin in pathological scar.ResultsThe expression of Smad3 in group A and B was not distinct from that in group C(p > 0.05), but the intranuclear accumulation is obvious. The expression of P-catenin was positive or strong positive in most fibroblasts of scar tissue, and higher than that in group C. There was significant difference between them(p< 0.01). But their expression was not statistically difference between group A and group B(p> 0.05). ConclusionTGF-β/Smad pathway can activate Wnt/β-catenin pathway, then cause the transcription and expression of factors which control cell proliferation and differentiation, regulate dermic fibroblastic proliferation expression and secretion, inhibit apoptosis, and in the end, cause collagen persistent excessive deposition to form pathological scar. Inhibiting Smad3 and(or)β-catenin may be a new target of prevention and treatment of fibrous diseases and inhibition of the formation of scar.