| ObjectiveTo observe the effect of Huaiqiuang paiticles on lymphocyte subpopulation, immunoglobulins and the infection of children with primary nephritic syndrome.MethodTotally 101 patients(60 males and 41 females,1-14 years old) first diagnosed with PNS were randomly divided into group A (62 cases) and group B (39 cases). Group A was treated with prednisone and Huaiqihuang particles, while Group B was treated with prednisone only. Observe the level of lymphocyte subpopulation and immunoglobulins before the treatment(A0,B0),3months(A3,B3) and 6months(A6,B6) after treatment. Record the infection and relapse patients within 6 months. Group C was control group (22 healthy children,13 males and 9 females).Result1 The CD8+T lymphocytes in group AO and BO were significantly higher than that of group C(P<0.05),while the CD4+T lymphocytes were significantly fewer (P<0.05),the proportion of CD4+to CD8+was significantly decreased, even inversion (P＜0.05).The level of NK cells in group AO and BO were significantly fewer than that of group C (P＜0.01). The IgA and IgG in group AO and BO were significantly fewer than that of group C (P<0.05, P<0.01). 2 3 month after treatment, the total T cells in group A3 was significantly higher than that of group A0,B3 and group C (P<0.05); the CD8+T cells in groupA3, AO and B3 were higher than group C(P<0.05), but there were no difference among groupA3, AO and B3; there were no difference of the CD8+T cells between group B3 and B0, which were both higher than that of group C(P<0.01); the CD4+T cells in groupA3, AO and group C were higher than that of group B3(P<0.01), but there were no difference among groupA3, AO and C; there were no difference of the CD4+T cells between group B3 and B0, which were both lower than that of group C(P<0.01);the CD4+/CD8+of group A3 and AO were higher than that of group B3(P<0.05),but lower than that of group C(P<0.05), there were no difference between group A3 and A0; the CD4+/CD8+of group B3 and BO were lower than that of group C(P<0.01), there were no difference between group B3 and B0(P<0.05); NK cells in group A3 was higher than that of group AO(P＜0.01) and group B3(P<0.05),but had no difference with groupC; NK cells in group B3 was higher than that of group B0(P<0.01),but had no difference with groupC; total B cells in group A3 was lower than that of group A0,B3 and C(P<0.01), total B cells in group B3 was lower than that of group B0, but had no difference with groupC; IgA in group A3, AO and B3 were lower than that of group C(P<0.05),but there were no difference among group A3, AO and B3; IgA in group B3 and BO were lower than that of group C, but there was no difference between these two groups; IgG in group A3 was higher than that of group A0(P<0.01),lower than that of group C(P<0.01),but there was no difference with group B3; IgG in group B3 were higher than that of group B0(P<0.01), but still lower than groupC(P＜0.01); IgM in group A3 was lower than that of group A0(P<0.01), but there were no difference with group B3 and C; IgM in group B3 were lower than that of group BO(P＜0.01);3 6month after treatment, there were no differences of the total T cells among the group A6, A3, B6 and C; there were no differences of CD8+T cells and CD4+T cells among the group A6, A3, B6 and C; there were no differences of CD8+T cells and CD4+T cells among the group B6, B3 and C; the CD4+/CD8+in group A6 A3 and B6 were lower than that of group C(P<0.01), there were no differences among group A6 A3 and B6; the CD4+/CD8+in group B6 and B3 were lower than that of group C(P<0.01), there were no differences between group B6 and B3; there were no differences of NK cells among group A6, A3,B6 and C, there were no differences of NK cells among group in group B6,B3 and C; total B cells in group A6 was lower than that of group C(P<0.05), there were no differences between group B3 and C, there were no differences of total B cells among group B6,B3 and groupC; there were no difference of IgA among group A6,A3,B3 and group C, there were no difference of IgA among group B6,B3 and group C; IgG in group A6,A3 and B6 were lower than that of group C(P<0.05), there were no differences among group B6,B3 and groupC; there were no difference of IgM among group A6,A3,B3 and group C, there were no difference of IgM among group B6,B3 and group C;4 The infection times of group A (12.9%,upper respiratory tract infection 6 times, pneumonia 2 times) were significantly fewer than group B (33.33%, upper respiratory tract infection 8 times, pneumonia 3 times, urinary tract infection 2times), and the relapse cases of group A (4,6.45%) were fewer than group B (6,15.38%).5 Side effect of Huaiqiuang particles, severe diarrhea(lcase).ConclusionThe cell immunity and the body fluid immunity is decreased and disturbed before theapy; the Huaiqihuang particles can improve the ability of NK cells and T help cells, decrease the infection and relapse of nephrotic syndrome; at the same time, Huaiqihuang particles has milt side effects.
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