High Risk Factors Analysis Of Ventilator-associated Pneumonia In Infants After Cardiac Surgery

Objective:To explore high risk factors of the postoperative ventilation-associated pneumonia (VAP) in infants with congenital heart diseases (CHD).Method:A retrospective study was conducted in 143 patients who had the hours of mechanical ventilation≥48h. Among the patients, mechanical ventilated infants who suffered VAP were included in an observation group, and non-VAP infants were in a control group.Case-control method, single-fastor analysis with Chi-square test and t test, and multiple logistic regression were performed to determine risk factors such as gender, need for reintubation, duration of mechanical ventilation, and so on.Result:There were 59 episodes of VAP in 143 patients who were mechanically ventilated more than 48 hours. The incidence of VAP was 41.3%. By single-fastor analysis, preoperative antibiotic, need for reintubation, duration of mechanical ventilation, with use histamine2-receptor blockade or antacid, time of cardiopulmonary bypass (CPB), postoperative low cardiac output syndrome and with sepsis are relate with development of VAP (P<0.05).By multiple logistic regression analysis, preoperative antibiotic, need for reintubation, duration of mechanical ventilation, with use histamine2-receptor blockade or antacid are closely related with development of VAP(P<0.05). Conclusion:Incidence of VAP in infants after cardiac surgery are high, with many high risk factors, which is the result of comprehensive action of external environment and internal environment of infants after cardiac surgery. A comprehensive prevention and treatment may be the best way to manage VAP.