Clinical Analysis Of 55 Patients With Acute Myelitis

Objeetive:Our purpose in this study was to evaluate and review the onset age, risk factors, CSF and neuropsychologic abnormalities, clinical profiles, steroids therapy and prognosis in patients.Methods:We chose 55 patients with were reviewed retrospectively from first affiliated hospital of jilin university between Jan 2000 and Dec 2009.The patients were divided according to steroid therapy into two groups: methylprdnisolone groups 26 patients and dexasone groups 29 patients. To analyze steroid therapeutic efficacy.Results:The most common first clinical symptoms included motorloss and sensory disturbance 55patienis(100%), which were tetraplegia or paraplegia,all sensory loss below the level, bladder and bowel paralysis. Sometimes cervical cord ischemic patients with respiratory insufficiency. Screenage examination (MRI) abnormal 46 cases, the classic image was hyperintensity on T2WIs, accompanied with hypointensity on T2WI. The therapeutic effect of methylprdnisolone was signifcantly better than that of control(P<0.05). The curative and effective rate in methylprdnisolone groups and dexasone groups were statistically significant obviously. (P<0.05).Conclusion:The onset age of acute myelitis between 15 and 71 years,mean age,41.9 years.And the age of onset between 20 and 50 years accounts more than half,totle 34 patients (61.8%). Two weeks before development of disease,most had got infected history(50.9%) or vaccination (1.8%).Their first clinical feature of sensiormotor deficts makes the greatest propotion.All sensory loss below the level,atonic urinary baldder and paralytic ileus.Sometimes cervical cord present with respiratory insufficiency. MRI was sensitive mostly and abnormality from ictus.,also can display the number of spinal cords which were ruined and the extent of the lesion. The classical image was hyperintensity on T2WIS, accompanied with hypointensity on T1WI and cord swelling.Sagittal view is most clear to observe spinal cord lesion. Methylprdnisolone may effective control the progress of disease. And we also pay attention to contraindication. Side effects were relatively less.