The Immunohisochemical Differential Diagnosis Of Mesenteric Fibromatosis, Solitary Fibrous Tumors And Gastrointestinal Stromal Tumors | Posted on:2011-01-24 | Degree:Master | Type:Thesis | Country:China | Candidate:J H Shi | Full Text:PDF | GTID:2144360305451804 | Subject:Pathology and pathophysiology | Abstract/Summary: | PDF Full Text Request | ã€Objective】To study the immunohistochemical features of mesenteric fibromatosis, solitary fibrous tumors and gastrointestinal stromal tumors and and discuss the differential diagnosis of these three diseases.ã€Methods】The expression of CD117,CD34,β-catenom,S-100,Desmin,Bcl-2 and Dog-1 of these three tumors was studied by immunohistochemistry method(S-P method).ã€Results】①There are 6 cases(75%) ofβ-catenin positive immunohistochemical staining among 8 cases of mesenteric fibromatosis. All 13 examples of GIST and 7 examples of solitary fibrous tumors lack labeling forβ-catenin.â‘¡There are over 85 % of CD117 and Dog-1 positive immunohistochemical staining among 13 cases of GIST. All 8 examples of mesenteric fibromatosis and 7 examples of solitary fibrous tumors lack labeling for CD117. All 8 examples of mesenteric f i bromatos i s lack labeling for Dog-1.â‘¢There are only few Dog-1 positive immunohistochemical staining among 8 cases of mesenteric fibromatosis. There are over 71% of CD34 and Bcl-2 positive immunohistochemical staining among 7 cases of solitary fibrous tumors. There are only few CD34 positive immunohistochemical staining among 13 cases of GIST.ã€Conclusion】We think we can identify mesenteric fibromatosis, solitary fibrous tumors and gastrointestinal stromal tumors by combining applying CD117, CD34, P-catenin and the morphous feature of HE staining slices. We can further eliminate myogenic tumors and neurogenic tumors by combining S100 and Desmin。...
| Keywords/Search Tags: | Interstitialoma, Immunohistochemistry, CD117, CD34, Dog-1 | PDF Full Text Request | Related items |
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