Relation Between Blood Glucose Level And Mild Cognitive Impairment After Acute Ischemic Stroke

Background and Objective:Mild cognitive impairment (MCI) is a recently described syndrome that is currently thought of as a transition phase between healthy cognitive ageing and dementia, which can be the single or dominant presenting feature of stroke. Many studies generally show a yearly incidence of dementia from MCI of 10～15%, which is about ten times greater than an age-matched population. As a transition phase, MCI has important clinical features of early dementia, attracting more attention. Hyperglycemia is often detected at the time of acute ischemic stroke and has been linked to worse outcome. We aimed to test the association of blood glucose level and MCI after acute ischemic stroke.Methods:Consecutive patients admitted to hospital in Department of Neurology were assessed with MoCA in 14 days after acute ischemic stroke. MoCA<25 is divided as MCI group, MoCA≥25 is divided as NO-MCI group. Basic demographic data, neurological deficit (National Institutes of Health Stroke Scale), infarct size and location were recorded when addmission. Fasting blood glucose level was taken in the morning of next day. We defined HG(high glucose level) as BG>6.1mmol/L. Logistic analysis were performed to find the association of blood glucose level and MCI after acute ischemic stroke.Results:Of 82 patients,51 had MCI (62.2%) and 36 had HG (43.9%). Age,years of education, history of stroke, NIHSS and blood glucose level were significantly different between MCI group and NO-MCI group. By regression analyses, hyperglycemia is not a risk factor of MCI, but history of stroke, high NIHSS and cortical infarction are the risk factor of MCI. Conclusions:Mild cognitive impairment (MCI) was common in acute ischemic stroke. Patients with high blood glucose level are likely to be mild cognitive impairment, but HG was not a risk factor of MCI. History of stroke, high NIHSS and cortical infarction are the risk factor of MCI.