Effects Of Expression On GFAP,NCAM And GABA Receptor In The Rat Hippocampus After Prenatal Exposure To 1800MHz Radiofrequency Field

Objective:To identify effects of expression on GFAP,NCAM and GABA receptor in Rat Hippocampus after prenatal exposure to 1800MHz Radiofrequency Field.methods:32 SD(Sprague Dawley) Female rats at age of 7 week-old were ran domly divided into four groups(8 rats in each) after one week for environment al adaptation and successful mating.Rats in the exposure groups were respective ly and continuously radiated between 0 days of pregnancy and 20 days of pre gnancy(12 hours/day) by 1800MHz microwave fields with power density of 0. 5 mW/cm2 or 1.0 mW/cm2.Simultaneously,two sham-controls were carried out r espectively. When the offspring were 3 week and 7week old we randomly sele cted eight pups from each group and dissected the brains.The brains tissue sect ions were performed by immunohistochemistry to demonstrate the expression of GFAP,NCAM and GABA receptor. Immunoreactivity in the hippocampus was analyzed by computer assisted image analysis system.Results:in the 0.5 mW/cm2 exposure group GFAP,NCAM,GABA receptor expression:decrease in the area of CA1,CA3,and DG of 3 week old and 7 week old rats's hippocampus.Compared to the control groups,there was significant difference. In the 1.0 mW/cm2 exposure group GFAP,NCAM,GABA receptor expression: increase in the area of CA1,CA3,and DG of 3 week old and 7 week old rats's hippocampus,Compared to the control groups,there was significant difference.Conclusion:there was a decrease in the expression of GFAP,NCAM and GABA receptor in the area of CA1,CA3,and DG of hippocampus in 3 week old and 7 week old rats after prenatal exposure to 1800MHz radiofrequency field with power density of 0.5mW/cm2.