The Relationship Between Helicobacter Pylori Cytotoxin-Associated Protein A(CagA) And Atherosclerotic Cerebral Infarction

ObjectiveExplore the relationship between helicobacter pylori cytotoxin-associated protein A(CagA)and atherosclerotic cerebral infarction.MethodsPlasma levels of anti-CagA IgG,neutrophilic leukocyte,C-reactive protein,plasma glucose,lipid and fibrinogen were determined in 100 patients with atherosclerotic cerebral infarction and 50 normal controls.The presence of plaque instability was evaluated by color Doppler ultrasound.Hp-antibody positive patients received anti-Hp therapy.ResultsThe positive rate of CagA-Hp antibody was 62%in patient group and 38%in control group,there was a significant difference between the two groups(P＜0.05).There was a significant diference of the percentage of carotid atherosclerotic plaque and arteriostenosis between the patients with positive Hp antibody(100%,61%, respectively)and the normal controls(55%,18%,respectively)(P＜0.05).Plasma levels of CRP and fibfinogen were significantly higher in Hp antibody positive patients than in Hp antibody negative patients(P＜0.05 1.Anti-Hp therapy may promote the recovery of cerebral infarction.ConclusionCagA-positive strains infection may be an independent risk factor for atherosclerotic cerebral infarction.