The Protection Effect Of Banxiaxiexin Decoction And Its Composing Medicine On The Gastric Mucous Membrance Induced By Hp And The Influence On Its Relative Factors

Objective:To investigate the effects of Banxiaxiexin Decoction and its composing medicines on the contents of Nitricoxid(NO),Interleukin-8 (IL-8) and Interleukin-2(IL-2) Banxiaxiexin Decoction on stomach induced by Helicobacter pylori(Hp) in mice,compare the rehabilitative effects of Banxiaxiexin Decoction and its composing medicine on the gastric mucous membrane,explore the mechanism of protection and rehabilitation on the gastric mucous membrane induced by Hp,and then provide the experiment evidence for the clinic on the preventing and curing gastric disease induced by Hp.Method:Mice were randomly divided into control group and model group.The model was prepared by injecting Hp to stomach among mice and treated by injecting drugs to gastric.After treated,mice were executed by heart blooding.The stomach and serum were saved.The stomach wet embeded,sliced up and dyed by HE.Observe the stomach changed on conformation and detect the contents of NO,IL-8 and IL-2. Results:1.The inflammation soakage in gastric of model group were was significantly increased compared with vacuity control group (P＜0.01).The expression of soakage in Banxiaxiexin Decoction group, bitter flaver and cold nature plus sweet flaver and warm nature group, positive control group,bitter flaver and cold nature group,Pinellia tuber plus bitter flaver and cold nature group was markedly decreased compared with model group(P＜0.01 or P＜0.05).2.The content of NO in serum was significantly enhanced in medol group(P＜0.01).The content of NO in Banxiaxiexin Decoction group,bitter flaver and cold nature group,Pinellia tuber plus bitter flaver and cold nature group,The bitter flaver and cold nature plus sweet flaver and warm nature group was reduced remarkably when compared with that in model group(p＜0.01). 3.The expression of IL-8 in model was markedly increased(P＜0.01).The expression of IL-8 in Banxiaxiexin Decoction group,bitter flaver and cold nature group,Pinellia tuber plus bitter flaver and cold nature group, bitter flaver and cold nature plus sweet flaver and warm nature group was decreased significantly compared with that in model group(P＜0.01). 4.The content of IL-2 in model group was reduced remarkably in serum(P＜0.01).The content was changed mostly significant in Banxiaxiexin Decoction group when compared with that in model group (P＜0.01).The content in bitter flaver and cold nature plus sweet flaver and warm nature group was decreased compared with that in model group (P＜0.05).Conclusion:1.The infection of Hp can injure gastric mucous membrane, increase the content of NO,IL-8 and decrease the content of IL-2 in serum.2.The Banxiaxiexin Decoction can protect and rehabilitate the gastric mucous membrane infected by Hp in mice.The main approach was to inhibit and destroy Hp,reduce the content of NO,IL-8 and increase the content of IL-2.3.When compared with composing medicine groups, the effect of Banxiaxiexin Decoction was best This came from Concurrent Treatment of Both Cold and Heat,Pungent Drugs for Dispersion and Bitter Drugs for Purgation,combining attact and supply in Banxiaxiexin Decoction.