Effect Of Butylphthalide On The Expression Of S100 In Alzheimer Model Rats

Objective:To determine the expression of S100 protein in hippocampal astrocyte in Alzheimer disease(AD) model rats,and to determine the effect of Butylphthalide on it and its significance.Methods:Sixty male adult rats were randomly divided to a model group,a Butylphthalide group,and a control group.AD models were established by injecting beta-amyloid protein 1-42 into the hippocampus in rats.Sixty days later,the rats were sacrificed and the hippocampus of both sides were prepared to sections for immunohistochemistry.Results:Compared with the control group,the positive cells of S100 and in the hippocampus of the model group increased,with statistically significant difference(P＜0.01).Compared with the model group,the positive cells of S100 in the hippocampus of Butylphthalide group decreased,with statistically significant difference(P＜0.05).Conclusions:The expression of S100 protein in CA1 of hippocampal astrocyte in Alzheimer model rats increases.Butylphthalide can inhibit the expression of S100 protein.