| OBJECTIVETo explore the relationship between high density lipoprotein cholesterol (HDL-C) and coronary heart disease(CHD).METHODAll objects are accepted Judkins of coronary angiography .427 CHD patients diagnosed by coronary angiography were selected as cases, and 306 non-CHD patients were selected as controls. Serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoproteinA1(ApoA1), apolipoprotein B (ApoB), lipoprotein (a)(LP (a)), free fatty acids (FFA) were compared with or without CHD, also these parameters were analyzed in 1-vesseal group, 2-vessel group and multi-vessel group of CHD patients. And finally through multiple regression analysis, the correlation of development and severity of coronary heart disease and risk factors was analiyzed. RESULTSThe overall prevalence rate of coronary heart disease is 58.25% (male 68.84%, female 49.20%). Compared with non-CHD group, the level of age, Cr and 2hPBG of CHD group was significantly higher (P <0.01). The level of Bun, FIB and HbA1C in CHD group was also higher than that in non-CHD group (P <0.05). The level of HDL-C, ApoA1 of Coronary heart disease group was significantly lower than that in the control group (P <0.05), while TC and LDL-C increased significantly (P <0.05, P <0.01); The level of TG, ApoB, Lp (a), FFA in coronary heart disease group was also higher than that in the control group, but without statistical significance.The level of HDL-C in CHD group was significantly lower than that in non-CHD group(P<0.05). In CHD group, HDL-C decreased gradually with the increasing number of coronary artery disease branch(P<0.05). Logistic multiple regression analysis, low HDL-C level was an independent risk factor for coronary heart disease.CONCLUSIONHDL-C was negatively correlated to the development and severity of coronary heart disease. TC / HDL-C may have a better predictive value in coronary heart disease.
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