The Relationship Between Non-high-density Lipoprotein Cholesterol And Coronary Heart Disease

Objective:To analyze the relationship of non-high-density lipoprotein cholesterol with coronary heart disease and coronary artery lesion severity, andto provide certain reference for the prevention and treatment of coronary heart disease.Methods:Choose374patients who were from February2012to February2013, the First Affiliated Hospital of Shanxi Medical cardiovascular medicine chest pain, chest discomfort of patients admitted to hospital to be diagnosed as coronary atherosclerotic heart disease, and coronary angiography.207cases were male,167female patients.Exclusion criteria:Nearly a month oral administration used statins or other lipid-lowering drugs or severe liver and kidney failure, thyroid disease, autoimmune diseases, blood diseases, cancer hi story. According to results of coronary angiography divided Subjects into the control group (128cases) and coronary heart disease group (246cases).Including coronary heart disease group according to the number of diseased coronary branches were divided into single, double, triple vessel disease group,According to the the Gensini score results are divided into mild, moderate, and severe disease group. Collect all the subjects of clinical data and blood lipid test results,In accordance with the formula of non-HDL=TC-HDL calculation of non-HDL-C values, and statistical analysis.Result:1.Comparison of serum lipids in patients with different coronary lesion countrwith the increase in the number of diseased coronary branches, in addition to HDL showing a decreasing trend, the rest of the lipid parameters showed an increasing trend.Single-vessel disease group and the control group of non-HDL only difference was statistically significant (p<0.05),double, triple lesion group compared with the control group and single-vessel disease group were statistically significant differences of serum lipid levels(p<0.05),three-vessel disease group and double vessel disease group only TG and non-HDL difference was statistically significant(p<0.05).2.Comparison of lipid parameters between the different severity of coronary(Gensini score):TC, HDL, non-HDL compared between the different degree of coronary artery disease group differences were statistically significant(p<0.05).TG, LDL difference between the moderate disease group with mild disease group was not statistically significant (p>0.05).In severe lesions with mild to moderate disease group differences were statistically significant (P<0.05).3.Serum lipid levels and coronary severity (Gensini Points):HDL and Gensini score was negatively correlated with other indexes and Gensini score was positively correlated with non-HDL Gensini score was significantly stronger than the individual lipid parameters.Conclusion:Non-high-density lipoprotein cholesterol and coronary heart disease are closely related, which can be used as a predictor of coronary heart disease risk, and compared with the lipids individual indicators, a better correlation with severity of coronary artery disease in patients with coronary heart disease.