| Objective: To investigate the prevalence of non-alcoholic fatty liver disease (NAFLD), relating characteristics, and primary risk factors among 1309 health examination cases in the medical examination center of First Affiliated Hospital of Dalian Medical University.Object and Methods: Collected 1309 cases for routine health ex- amination in the medical examination center of First Affiliated Hospital of Dalian Medical University from January to May, 2007. Removed those cases who had the diseases and/or conditions as mentioned in "non-alcoholic liver disease diagnosis and treatment guidelines" amended in February,2006; excluded those who had serious cardiovascular and cerebrovascular diseases, cancer, renal failure and other major diseases. Among those cases, male were 755 and female 554, aged from 18 to 85-year-old. 296 cases were diagnosed as fatty liver disease (FLD) by B-mode ultrasound examination, of which 232 cases were male, 64 female, aged from 18 to 77 years old; the remaining 1013 normal cases were classified as control group, of which 523 were men, 490 women. The prevalence rates of NAFLD in the overall, men and women were calculated respectively; the characteristics and the changes between NAFLD and control groups in age distribution, blood lipids, liver enzymes, etc were assessed; the complications and risk factors for NAFLD were analyzed.Results:1.1309 people were investigated, 296 cases were diagnosed NAFLD,the overall prevalence rate was 22.62%, the male prevalence rate was 30.73% and the female 11.55%; the prevalence rate difference between men and women was statistically significant (P<0.05). After gender and age stratification, the prevalence peak age distribution for the male and the overall was 40～49 years old group, the prevalence were 38.33% and 29.84% respectively; For female, it was≥70 years old. Male prevalence rate was higher than that of female between the groups less than 50 years old and with statistically significant difference (P<0.05), but it was not the same for men and women more than 60 years old, female prevalence rate was higher than that of male with no statistical significance(P>0.05).2.The NAFLD group's age, body mass index(BMI), waist circum- ference, serum uric acid (UA), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (GLU), triglycerides (TG), cholesterol (Chol), low density lipoprotein (LDL), high density lipoprotein (HDL) on average were higher than those in control group, comparison between the two groups were significantly different (p < 0.001). The NAFLD group's alanine aminotransferase (ALT), gammaglutamyltrans- ferase (GGT) on average were also higher than those in the control group (P< 0.001, 0.05 respectively), and ALT was more significant.3.NAFLD group's complication incidences included abdominal obesity 93.24%, hypertension 51.69%, hypertriglyceridemia 51.35%, overweight 47.97%, obesity 43.24%, (overweight and obesity 91.22%), hypercho- lesterolemia 39.86%, diabete(including elevated fasting blood glucose)21.96%, hyperuricacidemia 16.22%, electrocardiogram abnormalities 9.12%. The prevalence rates of liver gallstone and kidney stone were 3.72%, 1.69% respectively. The rates of complications, between NAFLD group and the control group were statistical significance (P<0.05) with the exception for liver gallstone and kidney stone groups (P=0.316, 0.3). In which abdominal obesity, overweight and obesity, overweight, obesity, hypertriglyceridemia, hypertension, diabetes ( including elevated fasting blood glucose ) and hyperuricacidemia were more significant.4.NAFLD Risk factors: By multi-factor non-conditional Logistic regression analysis, increased body mass index (overweight and obesity), high triglycerides, elevated fasting blood glucose (including diabetes), increased waist circumference (abdominal obesity), high blood pressure, increased blood uric acid was positively correlated with the occurrence of NAFLD, their respective value of 0R was larger than 1, as independent risk factors for NAFLD. Increased body mass index and high triglycerides as well as elevated fasting glucose had the closest relationship with NAFLD.Conclusion: There is a relatively high prevalence rate of NAFLD; men is higher than women; the prevalence rate of overall, men and women have the characteristics that change with age; NAFLD easily combine with obesity, hypertension, hypertriglyceridemia, hypercholesterolemia, diabetes or elevated fasting glucose, hyperuricemia; increased body mass index, high triglycerides, elevated fasting blood glucose, increased waist circumference (abdominal obesity), high blood pressure, high blood uric acid are independent risk factors for NAFLD. |
