Overexpression Of Serum Response Factor In Human Esophageal Squamous Cell Carcinoma

AIM: To investigate the expression pattern of serum response factor(SRF)in human esophageal squamous cell carcinoma (ESCC) and to analyze its relationship with clinicopathologic parameters.METHODS: The protein expression of SRF in human esophageal cancer tissues and their corresponding normal mucosa was detected immunohistochemically (IHC) by means of tissue microarray (TMA). Its correlation with clinical characteristics was evaluated and analyzed by Chi square test and Kruskal Wallis text. All statistical analyses were performed by SPSS version 11.0.RESULTS: The increased expression of transcription factor SRF was 62.6% (72/115) in ESCC tissues compared with their matched normal esophageal epithelium. However, the expression of SRF did not show any obvious correlation with age, gender, histological grade, lymph node metastasis and depth of invasion.CONCLUSION: Increased expression of transcription factor SRF may play an important role in esophageal carcinogenesis.