Study On Epidemiology And Etiology Of HFMD

Purpose:The datum of HFMD epidemic situation in 2008,the case in hospital investigations, and the severe cases were searched for to analysis their epidemiologic features,the pathogeny and the key risk factors.Depending on the established methods of viral isolation and fast RT-PCR technology,we must make it clear that what on earth the pathogen and the genotype isolated strains from Shandong is.By comparing the preponderant strains from 17 cities,the regularity of the enterovirus genotype vicissitudes and variation could be confirmed.Materials and methodsAll the datum of HFMD epidemic situation in 2008 were collected by 'China Information System for Disease Control and prevention'.Population information was obtai ned from Shandong province statistics bureau.Case investigations were o collected by 140 county Centers for Disease Control and prevention.1837 samples of stool,swab,herpes,CSF and blood from the cases in hospital were test on the methods of viral isolation and fast RT-PCR technology in accordance with the＜Manual for the Virological Investigation of Poliomyelitis＞.All the datum were analyzed by Epi info 3.4.3.ResultsThere was an HFMD outbreak in Shandong province,the peak incidence occurred in May to July,with 0.3220‰of the attack rate,and total 32974 cases were reported in 2008.Male were much more than female,sex ratio is 1.80:1.Most of the cases were children less than 5 years,the age-specific peak incidence occurred from 2 to 3 years old.Each agespecific attack rate was different.All cases were distributed wide over 17 cities,140 counties and 1747 towns(90.42%) of Shandong province.The incidence of each city was different,and was bigger in the densely inhabited district than the sparsely inhabited district.The typical erythras in hand,food,mouth and so on were the predominant clinical manifestations The concurrent infection cases of EV71 and Cox A16 hayed the more erythra in hand than the other types were not different in fever, complication,erythra in food,mouth and buttocks.All patients recovered completely and no death.The HFMD outbreak was caused mainly by EV 71 and Cox A16,which were identified by conventional methods,and the strains of EV 71 were more than Cox A16.The patients due to EV 71 and Cox A16 were 66.00%in all the lab-confirmed measles cases,and in witch 24.4%were infected with EV 71 and Cox A16 concurrently. The severe cases were were mainly by EV 71 radically.The majority of HFMD did not have demonstrable epidemiology history.ConclusionThe cases of HFMD caused mainly by EV 71 and Cox A16 were very widespread in Shandong area in 2008,and they were dispersed premodinantly.Part of patients were infected with EV 71 and Cox A16 concurrently.EV 71 was the preponderant stran in the outbreak.Henceforth,to prevent and control HFMD,we should strengthen effective surveillance system,and devote ourself to the education of children,their families and teachers in the kindergarten.