The Changes And Related Factors Of Ankle-Brachial Index In 670 Elderly Patients With Hypertension

Objective:1. To investigate the distribution of cardiovascular risk factors and arterial pathological changes in elderly patients with hypertension.2. To study the change and related factors of Ankle-Brachial Index in elderly patients with hypertension.Methods:We analyzed the healthy check-up data in the Third Xiangya Hospital and Xiangtan Hospital Health Care Center between Jan. 2007 and Jan. 2008, and selected 670 elderly patients and non-elderly patients with hypertension respectively in random, which were documented on standardised case report forms,including ankle-brachial index (ABI), brachial-ankle PWV (baPWV), blood pressure (BP), hight, weight, fasting blood sugar(FBS), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), creatinine (Cr), uric acid (UA), and so on. Their characteristics between elderly patients and non-elderly patients with hypertension were compared, and the related factors of ABI were analyzed. We applied SPSS11.5 for Windows to analyze the datas.Results:1. The elderly patients with hypertension had significantly lower ABI values(1.05±0.18 vs. 1.10±0.14 cm/s, P<0.001), and higher baPWV values (1868±325 cm/s vs. 1490±304 cm/s, P<0.001) than non-elderly patients with hypertension. The prevalence of the elderly hypertensive atients with abnormal ABI values was significantly higher than non-elderly patients with hypertension (35.8% vs. 27.0%, P=0.001). And age, BMI, baPWV, HDL-C, LDL-C were associated significantly with ABI in patients with hypertension by logistic regression analyses (P<0.05).2. There was gender difference in the elderly hypertensive patients with abnormal ABI values, that is, male is lower than female (41.3% vs 58.7%, P<0.05). The elderly hypertensive patients with abnormal ABI values had higher systolic blood pressure ( 149.61±2.39mmHg vs. 144.23±22.67mmHg, p=0.001) and diastolic blood pressure (80.41±12.34mmHg vs. 78.62±10.33mmHg, p=<0.001 )than the elderly hypertensive patients with normal ABI values, as well as the prevalence of related cardiovascular risk factors, such as diabetes (45.8% vs. 33.4%, p=0.002), smoking (48.3%vs. 36.5%, p=0.003) , and coronary heart disease (55%vs. 46.7%, p=0.040) . The prevalences of in elderly hypertensive patients with abnormal ABI values were significantly higher than with normal ABI values (P<0.05). Multiple logistic regression analyses showed that Age, gender, blood pressure, blood lipid, history of diabetes, smoking were independently associated with abnormal ABI values.Conclusions:1. The elderly patients with hypertension had significantly lower ABI values, and the prevalence of the elderly hypertensive patients with abnormal ABI values was significantly higher than non-elderly patients with hypertension.2. Age, BMI, baPWV, HDL-C, LDL-C were associated with ABI values in patients with hypertension.3. Age, gender, blood pressure, blood lipid, history of diabetes, smoking were independently associated with abnormal ABI values.