The Effect Of A Low Mclecular Weight Heparin On Chemotherapy Induced Activation Of Hemostasis On The Ovarian Cancer

Objective:To investigate the changes of Plasma fibrinogen and D-dimer in Patients with ovarian cancer during chemotherapy and evaluate the effect of a single dose of a low molecular weight hepatin administered prior to the chemotherapy on markers of hemostatic activation .Methods:Clauss and colloidal gold method were used to determine the fibrinogen and D-dimer concentration in low molecular weight hepatin administered prior to the chemotherapy group (n=20) and simple chemotherapy group (n=30) plasma samples respectively before and after chemotherapy (1h,24 h,48 h).Results:1. The levels of fibrinogen after chemotherapy in simple chemotherapy group were lower than before chemotherapy, there was a significant difference between after chemotherapy 24 h and before chemotherapy(P =0.0001),but there were no significant differences after chemotherapy 1 h, 48h compare to before chemotherapy.(P =0.527 and P =0.385).The levels of D-dimer after chemotherapy were higher than before chemotherapy, there was a significant difference between 24h, 48h and before chemotherapy(P=0.0001及P=0.0001), but there was no significant differences after chemotherapy 1 h compare to before chemotherapy(P=0.773).2. The levels of fibrinogen after chemotherapy in LMWH group were lower than before chemotherapy, there was a significant difference between 24h, 48h and before chemotherapy(P=0.0001及P=0.0001), but there was no significant differences after chemotherapy 1 h compare to before chemotherapy(P=0.169). The levels of D-dimer after chemotherapy were not higher than before chemotherapy, there were no significant differences. (P=0.875,P=0.754,P=0.348)Conclusions:There were coagulation and fibrinolysis dysfunction in ovarian cancer patients. Chemotherapy can promote coagulation and fibrinolysis in ovarian cancer patients. A single dose of LMWH administered prior to chemotherapy can suppress hemostatic activation.