Discordance Of ER, PR, And HER-2 Status Between Primary And Recurrence Focuses Of Breast Cancer

Objective:Hormone and Herceptin therapy for metastatic breast canHER-2 is commonly based on expression of estrogen receptor(ER) and progestin receptor (PR),over-expression of HER-2 in primary breast canHER-2 ,but studies comparing receptor status in primary and recurrence focuses of the same patient are limited.This study was designed to investigate discordance of ER,PR,and HER-2 status between primary and recurrence focuses of breast cancer.Methods:Immunohistochemistry assay was used to detect expression of ER,PR,and HER-2 in primary and recurrence focuses of 45 cases of breast canHER-2. The discordance of the three factors was analyzed.Results:Postive rate of ER, PR in primary focuses is 62.2%,60%(28/45,27/45), respectly,significantly higher than that in recurrence focuses (37.8% 17/45, 31.1% 14/45 ) (P<0.01 ) .Postive rate of HER-2 in recurrence focuses is 62.2 %(28/45),significantly higher than that in primary focuses (26.7% 12/45)(P<0.01).Conclusions:Differences in expression level of ER,PR, and HER between primary and recurrence focuses of breast canHER-2 were significant, so we should think highly of the differences expression of ER,PR,HER-2 in our clinical practices.