Effect Of Laporascopic Radical Operation On Immune Function In Patients With Rectal Cancer

Object: With the widely develope of laparoscopic surgery for rectal cancer,it is very important to evaluate effect of laparoscopic operation on immune function in patients with rectal cancer.Therefore, the aim of this study is to investigate the effect of systemic immune response after laparoscopic surgery for rectal cancer。Methods:From Sep.2007 to Jul.2008,40 patients with rectal cancer underwent rectal resection.20 patients underwent laparoscopic rectal excision and the other 20 patients underwent open rectal excision.Fasting peripheral venous blood samples were obtained from all the patients on the 1st day before operation,the 3rd and 7th day after operation,then counted and compared the levels of CRP,CD3+ ,CD4+,CD8+ and NK cells and lymphocyte.Results:All radical rectal operation was completed successfully ,and no laparoscopic surgery conversion to open surgery。There was no significant difference in the levels of CRP at the 1st day before operation between open and laparoscopic groups(P>0.05). There was significant difference in the levels of CRP at the 3rd and the 7th day after operation between open and laparoscopic groups (P<0.05).There were no significant difference in the levels of CD3+ ,CD4+,CD8+ and NK cells at the 1st day before operation between open and laparoscopic groups(P>0.05). There were significant difference in The levels of CD3+ ,CD4+,CD8+ and NK cells at the 3rd and the 7th day after operation between open and laparoscopic groups (P<0.05).The recovery time of intestinal function after laparoscopic surgery is eralier than that in open group, the intraoperative bleeding volume in laparoscopic group was shorter than that in open group,there were significant difference between two groups(P<0.05).There were no significant difference between two groups in distal margin of tumor,node harvest and complication (P>0.05).Conclusion:Laparoscopic surgery for rectal cancer has less effects on the immune system than open surgery and is conducive to the body restoration. Laparoscopic and open excision for rectal cancer are equivalent in the required criteria of oncologic radicality.