Clinical Study On Relationship Between The Inflammatory Indicators Of The Community-acquired Pneumonia And Differentiation-Type Of TCM Syndrome

Objective:To study indicatrix of phlegmonosis of White blood cell(WBC) and its categorization, C-reactive protein(CRP),tumor necrosis factor-α(TNF-α) and integral of ripe neutrophil alkaline phosphatase(NAP) for each Syndrome Differentiation-type of community-acquired pneumonia disease,and to explore the regularity of Traditional Chinese Medcine Syndrome Differentiation-type(TCM-SDT) and clinical indicatrix of phlegmonosis,and to provide the evidence for objective differentiation of symptoms and signs and reference for treatment.Methods:Patients with community-acquired pneumonia were differented by adopting the TCM Syndrome Differentiation for five groups,including Syndrome of wind and heat invading the lung,Syndrome of phlegm-heat obstructing the lung,Syndrome of excessive heat at lung and stomach,Syndrome of heat disturbing mind and Syndrome of health qi missing and pathogenic factor remaining.There were 20 patients in each group.Otherwise,20 health adults were added for control group.White blood cell(WBC) and its categorization,C-reactive protein(CRP),tumor necrosis factor-α(TNF-α) and integral of ripe neutrophil alkaline phosphatase(NAP) were detected in every person.Then analysis the relationship between indicatrix of phlegmonosis and TCM Syndrome Differentiation.Results:1.The levels of WBC,percentage of heterophil granulocyte(DC),CRP,TNF-αand integral of NAP in patients community-acquired pneumonia are significantly different from those in control group(P＜0.01).2.The Syndrome Differentiation-type of patients with community-acquired pneumonia is related to the levels ofWBC,DC,CRP,TNF-α,and integral of NAP in patients.The level of indicatrix of phlegmonosis:Syndrome of Syndrome of heat disturbing mind＞Syndrome of excessive heat at lung and stomach＞Syndrome of phlegm-heat obstructing the lung＞Syndrome of wind and heat invading the lung＞Syndrome of health qi missing and pathogenic factor remaining.2.1 Compared The TCM group of white blood cells,WBC-Syndrome of wind and heat invading the lung,and Syndrome of health qi deficiency and pathogenic factor residue was not significant(P＞0.05),the other groups were significantly different.2.2 Compared the TCM group of CRP:Syndrome of wind and heat invading the lung group and Syndrome of excessive heat at lung and stomach,Syndrome of excessive heat at lung and stomach group and Syndrome of phlegm-heat obstructing the lung was not significant(P＞0.05),the rest of the group have statistical significance(P＜0.05).2.3 Compared the TCM group of the percentage of neutrophils and NAP points:the percentage of neutrophils:Syndrome of wind and heat invading the lung,Syndrome of health qi deficiency and pathogenic factor residue,group was not significant(P＞0.05),Syndrome of phlegm-heat obstructing the lung and Syndrome of excessive heat at lung and stomach group was not significant(P＞0.05 ),the remaining group were statistically significant,(P＜0.05). NAP points in the Syndrome of wind and heat invading the lung group and Syndrome of health qi deficiency and pathogenic factor residue,group was not significant(P＞0.05),compared with other groups has statistical significance.(P＜0.05 or 0.01).By correlation analysis,both in the card type has a significant inter-related.2.4 Compared TCM Syndrome Group of the TNF-α:TNF-αin the he Syndrome of wind and heat invading the lung group and Syndrome of health qi deficiency and pathogenic factor residue group was not significant(P＞0.05),compared with other groups has statistical significance. (P＜0.05 or 0.01).Conclusion:The different TCM-SDT of community-acquired pneumonia disease is related to levels of WBC,DC,CRP,TNF-αand integral of NAP.Combination of these indicatrix of phlegmonosis which is worth of TCM-SDT of community-acquired pneumonia disease can be used for objective indicatrix for Syndrome Differentiation.1.1 Early in the course of disease,WBC,DC,CRP,integral of NAP in the blood normal,CRP,TNF-αincreasing slightly,it can be used as a reference indicator of Syndrome of wind and heat invading the lung,1.2 Basically the same range of inflammatory indicators rising in Syndrome of phlegm-heat obstructing the lung,Syndrome of excessive heat at lung and stomach,according to WBC,NAP,these Syndromes can be identified.1.3 If the indicators are significantly higher,combined with the corresponding symptoms, Syndrome of heat disturbing mind can be defined.1.4 Late in the disease,the inflammatory indicators within the normal range,if the inflammatory indicators are in the normal upper limit,Combined with symptoms, dialecticing for Syndrome of health qi missing and pathogenic factor remaining stage, CRP,NAP clearly points than the other indicators.