The Relationship Between Cognitive Impairment And Ambulatory Blood Pressure

ObjectiveTo analyze the relationship between cognitive impairment and ambulatory blood pressure in the elderly patients with hypertension.MethodSixty patients with hypertension were assessed using multiple neuropsychological tests and measured by ambulatory blood pressure.ResultAfter being adjusted for age, gender, and education, MMSE showed significant negative correlations to the other indices in ambulatory blood pressure except for the load of diastolic blood pressure (DBP), and to 24h, daytime& nighttime pulse pressure (PP). The total score of CAMCOG-C was significant negatively correlated with 24h average systolic blood pressure (SBP), the load of nighttime SBP, and 24h PP. Some sub-scores of CAMCOG-C, such as learning memory, attention, and praxis showed negative correlations with some indices of ambulatory blood pressure, while learning memory, attention, praxis and thinking were negatively correlated with some indices of ambulatory PP and pulse pressure index (PPI).ConclusionThe rising of SBP and the load of SBP in patients with hypertension may cause cognitive impairment in some ways, and rising of PP & PPI may be one of the risk factor of cognitive impairment in patients with hypertension. ObjectiveTo investigate the changes and influence of 24-h ambulatory blood pressure (ABP) in patients with mild cognitive impairment (MCI).Methods1. Thirty patients with MCI and thirty age, sex, education marched cognitively normal individuals were assessed using multiple neuropsychological tests.2. Thirty patients with MCI and thirty age, sex, education marched cognitively normal individuals were measured by ABP.3. Leukoaraiosis (LA) are determined by MRI.ResultsCompared with the control group, there are significant lower scores in orientation, language, memory, attention, calculation, and praxis (P<0.05-0.001) in the MCI group. The MCI group has significant higher levels of average 24-h systolic blood pressure (SBP), average daytime and nighttime SBP, load of average nighttime SBP and diastolic blood pressure (DBP), average 24-h pause pressure (PP), and average nighttime PP than the control group (P<0.05-0.001). Nondipping is also associated with the prevalence rate of MCI (P<0.05).The prevalence rate of leukoaraiosis in the MCI group is significant higher than that in control group.ConclusionsAbnormal high ambulatory SBP, especially at night .PP levels, and nondipping are associated with MCI. Leukoaraiosis may play an important role in the prevalence of MCI.