Effect Of Amlodipine,Terazosin And Its Combination Therapy On Reduction Of Postvoid Residual And The Analysis Of The Riskfactors For Baseline Postvoid Residual

Purpose To explore the factors for the patients with both hypertension and LUTS. And compare the efficacy of amlodipine terazosin and the combined group in improving the PVR in the subjects.Method All the subjects came from a research program aming to explore the effecacy and safety of amlodipine terazosin and its combination applied to the patients with both hyperhension and LUTS. Totally 360 patients had been inrolled.All the 360 subjects been diveded into 3 parallel groups in a prospective clinical trial,which are amlodipine /5mg, Terazosin /2mg and the combination group respectively. And the time for taking the pill between 20:00pm and 21:30pm. After 4 weeks treatment, 325 of 355 patients finished the trial. We defined the work definition of 50ml of PVR as the cutting point, 278 and 82 of the 360 patients had been devided into low PVR and high PVR group respectively. PVR IPSS scores BOO OAB SBP DBP and other characteristics had been collected. T-test andχ2 test and been used to single factor while logistics had been used to multiple factors analysis. Non-parameter test and regression analysis had been used to effecacy and safety of amlodipine terazosin and its combination therapy.Result The single factor analysis showed that age, WHR, smoke, current frequency of sex life and weekly intake of bean had a significant relation with the size of PVR, its p value were 0.03,0.05,<0.01,0.01,<0.01 respectively. Multiple analysis demonstrated that smoke (OR=0.64, P<0.01), weekly intake of bean (OR=0.47, P<0.01) and WHR had statistical significancy. After 4 weeks treatment, amlodipine significantly reduced the PVR(ΔPVR=6.8, P <0.01), the combination group also reported reduction in PVR(ΔPVR=8.8, P <0.01). In stratified analysis, patients with high baseline PVR(≥50ml) reached a greater PVR reduction in all the three groups. Amlodipine reduced the PVR(ΔPVR=51.9, P <0.01), Terazosin reduced the PVR (ΔPVR=66.1, P <0.01), the combination group reduced the PVR(ΔPVR=60.5,P <0.01).Conclusion WHR had a positive relationship with inlargement of PVR, while smoking and weekly intake of soybean had a negative relationship with the inlargement of PVR. Smoking and the intake of soybean may participate the metabolism of the sex hormone, then affect the lever of PVR. Amlodipine and its combination with terazosin had good efficacy on improving the PVR,reducing the risk of AUR in the patients with lower urinary tract symptoms, especially in the patients whose baseline PVR above 50 ml,but demonstrated no difference compared with terazosin. Our findings provide a new indication for chosing a more efficient and comprehensive proposal for the patients with LUTS and hypertension in clinics.