Correlation Of Rs4085613 Polymorphism Within The Late Cornified Envelope 3D Gene With Some Clinical Features Of Psoriasis Vulgaris In Chinese Han Population

Background Psoriasis (OMIM#177900) is a common, chronic and recurrent, inflammatory skin disease. Both genetic and environmental factors play important roles in the pathogenesis of psoriasis. Psoriasis vulgaris (PV) is the most frequent clinical type. We found a distinguished correlation of rs3213094 polymorphism in LCE gene cluster with psoriasis vulgaris in Chinese Han Population by psoriasis genome-wide association study (GWAS).Objective Based on stratifying analysis of the age of onset, family history and clinical types, the study compared the genotype distribution of rs4085613 polymorphism within LCE3D gene with some clinical features of psoriasis vulgaris in the Han Chinese population in order to further explore the genetics pathogenesis.Methods We analyzed the distributions of genotype and allele of rs4085613 polymorphism within LCE3D gene in 1,139 cases and 1,132 normal controls, which derived from the psoriasis genome-wide association study (GWAS). The appropriate application of social science statistical software package SPSS 15.0 was used for statistical analysis of data.Results 1. The genotype frequency of rs4085613 polymorphism within LCE3D gene was of statistical significance between the cases and the controls (χ²=33.71, df=2, P=4.79×10-8), there was a similar trend for the allelic frequency (χ²=31.85, df=1,P=1.67×10-8, OR 1.41, 95%CI 1.25-1.59). 2. The genotype and allelic frequencies of rs4085613 polymorphism were statistical significance between the pediatric age of onset cases and controls (χ²=14.48, df=2, P=0.001;χ²=12.86, df=1, P=3.35×10-4, OR 1.38, 95%CI 1.16-1.65). The genotype and allelic frequencies of rs4085613 polymorphism were also statistical significance between the adult age of onset cases and controls (χ²=27.99, df=2, P=8.36×10^-7;χ²=27.35, df=1, P=1.70×10^-7, OR 1.42, 95%CI 1.25-1.62). However, there weren't statistical significance between the pediatric age of onset and adult age of onset cases (χ²=1.10, df=2, P=0.58;χ²=0.08, df=1, P=0.78, OR 0.9, 95%CI 0.81-1.17). Meanwhile, there wasn't significant difference among the age of onset for the rs4085613 genotype frequency (all P>0.05). 3. The genotype and allelic frequencies of rs4085613 polymorphism within LCE3D gene were statistical significance between the familial cases and controls (χ²=19.70, df=2, P=5.27×10-5;χ²=19.19, df=1, P=1.18×10-5, OR 1.44, 95%CI 1.22-1.69). The genotype and allelic frequencies of rs4085613 polymorphism were also statistical significance between the sporadic cases and controls (χ²=24.14, df=2, P=5.71×10^-6;χ²=23.02, df=1, P=1.60×10^-6, OR 1.40, 95%CI 1.22-1.61). However, there weren't statistical significance between the familial and sporadic cases (χ²=0.11, df=2, P=0.95;χ²=0.09, df=1, P=0.77, OR 1.03, 95%CI 0.86-1.23). 4. The genotype and allelic frequencies of rs4085613 polymorphism LCE3D gene were statistical significance between the acute guttate cases and controls (χ²=13.83, df=2, P=0.001;χ²=10.71, df=1, P=0.001, OR 1.33, 95%CI 1.12-1.57). The genotype and allelic frequencies of rs4085613 polymorphism were also statistical significance between the chronic plaque cases and controls (χ²=30.41, df=2, P=2.50×10^-7;χ²=30.01, df=1, P=4.30×10^-8, OR 1.46, 95%CI 1.27-1.67). However, there weren't statistical significance between the acute guttate and chronic plaque cases (χ²=3.95, df=2, P=0.14;χ²=1.04, df=1, P=0.31, OR 0.91, 95%CI 0.76-1.09). Conclusions 1. The rs4085613 polymorphism within LCE3D gene is associated with the susceptibility of psoriasis vulgaris in the Han Chinese population. 2. PV patients with a peak incidence at 15-30 years of age, the rs4085613 polymorphism within LCE3D gene isn't associated with age of onset of psoriasis vulgaris. 3. The family history positive rate PV patients in the type 1 is higher than the sporadic PV patients in type 2, the rs4085613 polymorphism within LCE3D gene isn't associated with family history of psoriasis vulgaris. 4. The rs4085613 polymorphism within LCE3D gene isn't associated with clinical type of psoriasis vulgaris. 5. Our findings indicated that the rs4085613 polymorphism within LCE3D gene may have no effected on the age of onset, family history and clinical type, which maybe associate with different psoriasis genetic basis and pathogenesis.