The Relationship Between The Expression Of S100A8 And Caspase-3 In Esophageal Carcinoma And Their Clinical Significance

Purpose:To study the expression of S100A8 and Caspase-3 in human esophageal squamous cell carcinoma,and to investigate the correlation between their expression level and histopathological grade in these tumors.Methods:In this study,30 cases of esophageal squamous cell carcinoma were assessed for S100A8 and Caspase-3 expression using immunohistochemistry. Statistical analysis including Paired chi-square test,Fisher Exact test,Spearman's rank correlation were performed for the comparison of S100A8 and Caspase-3 expression in normal,dysplasiad and tumor tissues, and their relationship with clinicopathological features by SPSS 15.0.Results:Reduced or absent expression of Caspase-3 was observed in dysplasiad tissues,with a significant difference between dysplasiad and normal tissues(P<0.05),but no significant difference between tumor and normal tissues,and there's no significant association was found between its expression and histopathological factors;Reduced or absent expression of S100A8 was also observed in both dysplasiad and tumor tissues,with a significant difference between normal tissues(P<0.05),but no significant association with histopathological either.S100A8 and Caspase-3 were positively correlated in dysplasiad tissues,but not in tumor tissues.Conclusions:These findings suggest that the decreased expression of S100A8 and Caspase-3 might play an important role in the pathogenesis of human esophageal squamous cell carcinoma.