The Experimental Study On The Effect Of Panax Quinquefolium L On The Insulin Resirtance Rat

Insulin resistance refers to the function of glucose uptake function mediated by insulin was degrade,which causes that the secretary volume of insulin increase vicariously with a main feature of hyperinsulinemia.It is the significant feature of non-insulin-dependent diabetes mellitus(NIDDM) and the common pathomechanism of obesity,hypertension,lipid metabolism abnormality and atherosclerosis.This study aims at illuminating the effect and its mechanism of Panax quinquefolium L on the animal model of rat insulin resistance,thus laying foundation for the further study on the material basis of Panax quinquefolium L's application in insulin resistance,and providing the experiment foundation for Panax quinquefolium L's application in such insulin resistance relative diseases as diabetes,hypertension and so on.Objective:Study the effect and its mechanism of Panax quinquefolium L on insulin resistanceMethods:Regarded SD rat as the experimental subjects,induced insulin resistance by the high-fat food and streptozotocin(STZ),while normal control group fed a normal diet.Then treating with three different dosages Panax quinquefolium L and taking rosiglitazone as control group.after 6 weeks measuring Fasting Blood Glucose,Fasting Insulin and Insulin Sensitivity Index, Total Cholesterol,Triglyceride,Free Fatty Acid and leptin.Conclusions:1.Panax quinquefolium L can obviously improve insulin resistance rat's state, degrade fasting insulin and improve insulin sensitivity.2.Panax quinquefolium L can degrade the level of Total Cholesterol, Triglyceride and Free Fatty Acid,thus improving insulin resistance from the view of lipid metabolism.3.Panax quinquefolium L can improve the level of leptin,thus improving insulin resistance from the view of adipocyte...