Study On The Preparation And Quality Standard And Pharmacodynamic Evaluation Of Compound Shenma Capsule

Objective: to study on the extracting and preparing process and quality standard of Compound Shenma Capsule, furthermore, to evaluate the pharmacodynamics of which.Methods: the extracting process of Ginseng and Gastrodia rhizome was studied by orthogonal experiment design; optimized the parameter of micronization of Corydalis, and compared the traditional fine powder with superfine powder; because all the main active ingredients such as hyoscyamin, atropine in Datura flower have ester bond in their structures, which crushed in traditional way and screened by the sifter with 60 mesh in per inch; identified all the ingredients in the prescription by TLC, which is based on the reference medicinal material and reference substance, determined panaxsaponin Rg₁, Re, gastrodine, tetrahydropalmatine, scopolamine and atropine by HPLC; evaluated pharmacodynamics of Compound Shenma Capsule, the content include the therapeutic effect and influence to immune function and influence to neurotransmitter to animal model depending on morphine, etc.Results: the related parameters of extracting, purifying and preparing process technique is gotten, achieved the identification methods of every Chinese medicine, detemination methods of the main active ingredients. Furthermore evaluated preliminary pharmacodynamics of Compound Shenma Capsule.Conclusion: Compound Shenma Capsule have reasonable prescription, scientifical and advanced extract and preparation process, the quality standard is strict and controllable, clinical effect is positive, has less side-effect.