| Social progress and economic development, the material standard of living of human beings has been greatly improved, but along with the hiddenmentalstress, resulting in depression, self-blame, dislike of Health, loss, irritability, frustration, tension and mental disorders, These growing problems of life. Survey shows that anxiety disorders in our country the incidence of 2% - 4.7%, and with the people's work and accelerate the pace of life, increasing competition in the role of many factors such as increased incidence is rising. Modern medicine, the incidence of this disease with genetic, physiological, biochemical, psychological factors, and neural anatomy of the lesion site, and the main use of drugs and psychological treatment interventions, adverse drug reactions due to anti-anxiety, and difficult to tolerance, patients often a result of poor compliance with treatment interruption, thus seriously affecting the clinical efficacy. At present, many Chinese medicine based on pathogenesis and clinical experience, and be on the basis of traditional Chinese medicine diagnosis and giving of treatment effect better.PurposeThrough clinical observation of the subject of a preliminary evaluation of Yin and Yang, Ning Xin Da sedative effect of the particles in the treatment of generalized anxiety disorder the clinical efficacy and safety. MethodsCases are selected from December 2007 to October 2008 out-patient treatment in Chinese medicine hospital of Hubei Province, 72 cases of generalized anxiety disorder is TCM, the patients, the use of randomized, double-blind test components high-dose group, low-dose group and the placebo group control method of parallel, each group according to the ratio of 1:1:1, 24 cases each, followed by appointments to have medicine, medicine for six weeks and 0 weeks , 2 weeks, 4 weeks, 6 were carried out over the weekend Hamilton Anxiety Scale (HAMA) and traditional Chinese medicine symptom score, and statistical comparison of the clinical efficacy of 3 groups.Safety in the treatment of test items before and after the first day of that first visit and 42 days after administration of the first laboratory tests done to blood, urine, stool routine, liver and renal function, electrocardiogram as a safety indicators to determine whether the toxic particles Daan side effects.ResultsEfficacy of high-dose group of 5 cases markedly effective in 11 cases, five cases of slightly effective, ineffective or three cases of deterioration. The total effective rate 87.5% Low-dose group and 2 cases markedly effective in 7 cases, slightly effective in 9 cases, 6 cases of invalid or deterioration. The total effective rate 75.0% 0 cases of markedly placebo group, effective 1 cases, 6 cases of slightly effective, ineffective, or 17 cases of deterioration. The total effective rate 29. 2% By Ridit test, 3 groups Hamilton Anxiety Scale (HAMA), TCM Syndrome score of the week, with a total score compared effects were significantly different (P<0.05). High-dose group and low-dose group of Chinese medicine can improve symptoms, the improvement of high-dose group more than the main dream of insomnia patients and the role of fear obviously upset, palpitations alleviated. Mouth disease in咽燥times and five significant improvement in hot upset, forgetful little ringing in the ears, the tongue has improved pulse. On the part of low-dose group and the TCM Syndrome HAMA score lower in patients with sleep, irritability have improved. The placebo group no significant improvement.After the safety inspection, observation of patients with the three conventional, electrocardiogram, liver and kidney function, vital signs and other indicators show no significant toxicity Da particles, side effects, the use of security.ConclusionDa-an granule in the treatment of generalized anxiety disorder clinical trials in the exact effect on the drug for generalized anxiety disorder have a significant effect on clinical symptoms, at the same time safe and reliable.
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