| Purpose:This topic plans through the clinic research,the first step observes YI ZHI capsules to the senile dementia clinical curative effect and the security,inquirying into it to cure stupid function mechanism of old age,laying the foundation for the further research,to raise clinical curative effect and prevent and cure senile dementias to all have important meaning towards easing a sufferer pain and sufferings,.Method:1.Case of illness being selected object(1)The age >=50 and <=80 years old.(2)The men and women may(3)Conforms to DSM-â…£stupid diagnosi standard,the NINCDS-ADRDA old age is stupid to examine a patient standard, as well as Chinese medicine dialectical for the spleen kidney two falsely,the phlegm muddy blood jam-up certificate.(4)The simple intelligence appearance check meter(MMSE) grades point in >10 minute with <=24 minute between,and carries on adjustment according to the cultural degree,(the illiteracy bring into line with,the primary school degree less than 20,above degree less than in middle school 24)(5)Completely the decline quantity form(GDS) at in 3 expect to 5 periods,for is light,in the degree is stupid.(6)The Hachinski less than 4 cent,or have no the disease history or CVD behind more than 3 months but HIS is 5 divide,6 cent,may also bring into.(7)The HAMD less than 10 centses.(8)The weight is between the 50-90 Kg(9)Test-receiver voluntarily also test-receiver or serve as guardian a personnel to sign to know what happened an approval a book.(10)Have right understanding to the medicine research meaning, have to the researcher's observation and evaluation to obey sex goodly.(11)There is certain cultural degree,can write simple sentence.Any match above various inpatients or outpatient and all can bring into a clinical trial case.2.The case expels object(1)The heavy degree is stupid,namely the MMSE grade point less than 10 cent,or the GDS grade point>5 period.(2)Get blood vessel stupid(the HIS more than 7 cent) or there is other reason with the result that of stupid.(3)The HAMD more than 11 cents.(4)The physical endowment allergy,pulling the Aniracetan Capsules or other Pyrrolidone medicine to the Aniracetan Capsules can't bear to be subjected to.(5)Other researchers attends or is attending the Clinical within 4 weeks. 3.All cases is in November,2004 to December 2005 year Hubei Province Chinese medicine hospital nerve internal medicine department outpatient service and is hospitalized the patient,total the altogether 56 example,press to hospitalize to is divided into a treatment the set and matched control order of sequence and random,cure a set among them 28 examples,matched control is 28.Is divided into random two sets of basic balanced was learn by covariance in the age,sex,course of illness,and the condition degree examination,do not show the prominence difference(P>0.05), has the commeasurability.4.Experimental group:YI ZHI capsules,day three times,each time 5 grains,win supper an empress early 0.5-1 hour,the boiled water sends;Matched control group:The Aniracetan Capsules for day three times,each time 2 grains(add to imitate 3 grains of total 5 grains of),win the empress of the supper early 0.5-1 hour,the boiled water sends,period of treatment:It is one period of treatment for 3 months,take period of treatment totally.Shows the effect case with visit to the 9 monthses.Conclusio:This result of research indicated that YI ZHI capsules cure dementia(AD)(the spleen kidney two falsely,the phlegm muddy blood jam-up certificate),the curative effect shows the prominence and better than Aniracetan Capsules,three black capsules can improve a Dementia(AD) sufferer obviously of the study memory function.Ease stupid clinical symptom of old age, raise the sufferer's living quality.
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