| ObjectiveChronic bronchitis is the trachea,bronchial mucosa and surrounding tissues of chronic non-specific inflammation. Clinically to cough,sputum or with recurrent wheezing and chronic course characterized.Due to a recurring problem,the prevention and treatment delays,and complications of obstructive pulmonary emphysema,and even pulmonary hypertension,pulmonary heart disease,patients witha serious impact on the ability to work and health.With the aging of society and the increase of air pollution, the increasing incidence of chronic bronchitis increased.In our country,its incidence rate is about 3.82 percent of the population,the elderly about 15%,and in some areas as high as 20% -30%.ht present the view that air pollution,smoking,infection, allergic factors,genetic,climatic factors,autonomic dysfunction, and many other factors that triggered a major cause of chronic bronchitis.Acute stage and chronic treatment of the extension to move to control the infection,expectorant,antitussive mainly wheezing associated with asthma,when added spasmolytic drug.Remission of physical therapy to strengthen and improve the capacity and the prevention of recurrence of disease mainly glucocorticoid commonly used for this disease is airway inflammation ill effects,and long-term,side effects obvious.Therefore,the characteristics to play a traditional Chinese medicine to strengthen the basis of chronic bronchitis and clinical research,to reduce the relapse rate of chronic bronchitis,ease the symptoms of major social and economic benefits.Studies suggest that in the formation and development of chronic bronchitis during oxidative - antioxidative imbalance plays an important role.Research shows:Astragalus with Chinese Qi Yang-yuan,uphold and support the role of Tongmai effectiveness, etc.,on the acute stage,chronic patients with chronic bronchitis to move certain postponement.Based on the above research,this study proposed the use of smoke-induced rat model of chronic bronchitis,chronic bronchitis studies of Radix Astragali on serum superoxide dismutase(SOD) activity,from the perspective of antioxidant in the prevention and treatment of chronic astragaloside bronchitis may exist when the mechanism for the clinical application of the drug further,the development and promotion,providing a scientific basis for the experiment.MethodsKunming will be 30 healthy SD rats were randomly divided into 3 groups:normal control group,model control group andastragalus treatment group.Adaptive feeding rats a week after the beginning of the experiment.Normal feeding routine is not smoked,the model group Manzhi not have any role in drug prevention and treatment interventions,use of improved smoke law model,for each 30min, twice a day,for 25 days.RA group,together with the model group smoked at the same time,and model from the 1st day that the drugs administered decoction of Astragalus intervention,each 2.5ml, twice a day.This experiment and the model of administration in rats during the observation of mental activities,and hair,breathing, loss of appetite,weight,defecation,such as under normal circumstances.Model after the end of peripheral blood collected 3 rats,the serum SOD vitality.ResultsChronic bronchitis in serum levels of SOD vitality,low compared with the normal group,there are significant differences (P <0.01).Astragaloside in serum SOD activity and chronic bronchitis compared to the high side,some significant difference (P <0.01);slightly lower compared with the normal group,no significant statistical difference(P> 0.05).Conelusions1.hstragaloside chronic bronchitis can improve serum levels of SOD vitality that hstragalus can enhance the antioxidant capacity of the body to reduce oxidative damage,regulation of oxidative imbalance in one antioxidant.2.This study is more reasonable interpretation of the prevention and treatment of chronic bronchitis astragaloside the role of possible links exist,in order to promote the use of drugs and in-depth development of a new scientific basis for the experimental. |
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