Biomechanics Research Of Right Ventricular Systolic Function With Chronic Cor Pulmonle

Objective To evaluate the biomechanics characteristic of right ventricular myocardial systolic function in the patients with chronic cor pulmonale by using Acceleration during isovolumic contraction(IVA) and Yang elastic(E).Methods Right ventricular ejection fraction (RVEF),Right ventricular stroke volume(RVSV),Right ventricular anterior wall dimension (RVAWd) and Pulmonary artery systolic pressure(PASP) were determined by echocardiography in 70 cases of chronic cor pulmonale and 38 cases of normal control subjects. Patients with chronic cor pulmonale were divided into groups of light-mid lever group (30-70mmHg) and heaviness lever group(＞70mmHg)。Quantitative tissue velocity imaging (QTVI) were applied for obtaining the middle segments of RV free wall long axis strain curve and velocity curve,peak systolic strain(PSS),maxmum and minmum Isovolumic contraction velocity(ICVmax,ICVmin),Isovolumic contraction time(ICT) and calculating Acceleration during Isovolumic contraction(IVA)and Yang elastic(E).Result①IVA was decreased in two pulmonary hypertension(PH) groups(104.57±22.09 vs 118.88±22.94,p =0.023;91.47±19.40 vs 118.88±22.94,p=0.00),and it had significant difference between two PH groups(p＜0.05).②E was different in normal group and PH groups(3.83±1.93 vs0.62±0.30,p=0.026;12.11±8.11 vs 0.62±0.30,p=0.000),and was increased in PH groups,with significant difference(p＜0.01).③The PSS of the middle segments of RV free wall was decreased in two PH groups than in normal group(23.53±5. 92 vs 32.49±5.26,13.31±4.95 vs 32.49±5.26,p＜0.01),and had significant difference between two PH groups(23.53±5.92 vs 13.31±4.95,p＜0.01).④RVAWd had no significant difference between normal group and lightmid lever PH group(4.82±0.51 vs 5. 06±0.68,p=0.373),RVAWd of heaviness lever PH group was higher than that of light- mid lever PH group,had significant difference between normal group and heaviness lever PH group(4.82±0.51 vs 7.73±0.73,p〈0.01),and had significant difference between two PH groups(5.06±0.68 vs 7.73±0.73,p＜0.01).⑤ICVmax was gone down in heavness PH group(6.30±1.58 vs 5.05±1.62;6.50±1.49 vs 5.05±l.62,p＜0.01),but had no significant difference between normal group and light-mid lever PH group.⑥ICT was increased in PH groups,with significant difference(p＜0.01).⑦In three groups, there was no significant difference in RVEF,RVSV(p＞0.05).Conclusion Heart mechanics index of IVA and E got from echocardiography which was used to evaluate chronic cor pulmonary right ventricular myocardioal systolic function are able to reflect biomechanics characteristic of myocardium more objectively and also provide a dependable evidence for new clinical quantiative assessment of chronic cor pulmonary right ventricular myocardioal systolic function.