Clinical Presentation And Prognosis Of 53 Gerontic Patients With Guillain-Barre Syndrome

Background and PurposeGuillain-Barre syndrome is an acute inflammation of multiple nerve neuropathy, which is characterized by rapidly progress to limb weakness and weakening of tendon reflexes.Currently being considered to be due to T cell activation-induced immune disorder,resulting in targeting of peripheral nerve protein antibodies as a result of autoimmune diseases.Common infections,such as EB virus,Campylobacter jejuni,as well as immune injury or surgery are related to the generation of the autoantibodies. GBS occurs in children and adolescents in the incidence of the elderly is relatively low, but also in elderly patients with related clinical manifestations and prognosis fewer reports.In this paper,between the years 2000-2008 in our hospital over the age of 60 patients 53 cases were analyzed retrospectively to explore the elderly GBS clinical characteristics and prognosisMethodsWe retrospectively assessed the clinical manifestations,results of electrodiagnostic tests, functional status and prognosis of 53 patient diagnosed with GBS in Department of Neurology of our hospital from 2000 to 2008..We will discharge Hughes score(?)3 or discharged into the score difference＞0 is defined as a poor prognosis group,Hughes score＜3 points or Hughes score difference(?)0 is defined as a better prognosis.Good prognosis,respectively(n=30) and poor prognosis(n=23) groups of the prediction analysis of related factors.At the same time,according to Hughes score to improve the situation of the three treatment groups:IVIg group glucocorticoid group,IVIg + glucocorticoid group,parallel correlation analysis.ResultsDifferent form adult,upper respiratory infection was the most frequent preceding event,and limb weakness was the most frequent symptom at GBS onset.A worse outcome when discharge was related to a higher Hughes grade at admission,limb weakness,age＞or=60 years,complications(p＜0.05).And according to the treatment, there were three groups:IVIg,corticosteroids,IVIg+corticosteroids,however,the three groups did not differ significantly between the improvment of Huges scores.ConclusionsExist on the majority of gerontic GBS patients with a history of respiratory tract infection.A worse outcome was related to a higher Hughes grade at admission,limb weakness,age＞or=60 years,complications.Older age groups,the higher score Huges, various complications prompted the emergence of a poor prognosis.And the Erasmus GBS outcome score(EGOS) is a good way to predict the prognosis.