| The high blood pressure is the familiar disease that endangers mankind's health seriously with be taken bad much, also is the mankind's one of the important death reasons.Study currently widespread thinks th e original hair high blood pressure(the essential hypertention, EH) is the heredity and the environment factor a coefficient result. The mental state should arouse factor to have in the blood pressure go up of the occurrence important function, and the possibility is end to cause the occurrence that should arouse sex high blood pressure(the ress-induced hypertention, SIH), as to it's carries on the clinical topic that the valid prevention and cure has become the medical science field to wait for solve. Research certificate at various should under the intense emotion condition, circulate in the ALD and the CA increase. The last long blood plasma ALD and CA increase high, may be a SIH pathologic foundation.Based on the traditional Chinese science and the therapeutic principle of"Yi-Bing-Tong-Zhi" and"Tong-Bing-Yi-Zhi", with the main idea of"Ping-Gan-Qian-Yang"and"Huo-Xue-Li-Shui", JTC is pure traditional Chinese compound preparation summarized from years'clinical experience. Clinical observation confirmed that it could significantly lower the blood pressure of EH patients and had curative effect in hemorheology and cytorheology. For clarifying the clinical effect mechanism of the chrysanthemum rattan capsule further, we application the ELISA method,HPLC method etc. research means, further study the chrysanthemum rattan capsule to SIH the effect and mechanism, is that product clinical effect,development and expansion provide an experiment basis.Objective:Inquiry into JTC and should arouse to the chronic with the result that should arouse big rat blood pressure,the blood plasma aldosteroneand the influence of the catecholaminelevel.Methods:42 male SD rats were randomized into 6 groups. They were normal control group, model group, stress+JT-H group, stress+JT-M group, stress+JT-L group, stress+captopril group. Apart from the normal control group, the rats of other groups were made by chronic electrical foot-shock stimulation, with the power 30-48.5 V, frequecy 0.5 Hz, and given the drugs before stress every day, 4 h daily, for 28 d. The rats of the normal control group and model group were both fed with distilled water. We detected the levels of plasma aldosterone in rats of each group by ELISA, and determined the catecholamine of rats.Results:Received chronic foot-shock stress for 28 d, compared with the control group, the SBP of model group were significantly higher (P<0.01); As compared with the model group, the SBP of JTC-H group, JTC-M group and captopril group were lower(P<0.01).As compared with the control group, the chronic stress significantly increased the level of ALD of the model group (P<0.01); and compared with the model group, the level of ALD were lower in JTC-H group, JTC-M group, JTC-L group and captopril group (P<0.01).As compared with the control group, the chronic stress significantly increased the level of NE and E of the model group (P<0.01); and compared with the model group, the level of NE and E were lower in JTC-H group and JTC-M group(P<0.01).The level of the JTC-H group and the normal group is equal.(P>0.05) . The captopril group can lower the function of the NE and E, but be still higher than a normal group.(P<0.01).Conclusions:1. JTC can effectively reduce SBP the stress-induced rats.2. The JTC can reduce the circulating ALD by blocking the way of ALD producing , have the function of the similar ACEI;3. The JTC reduces circulating CA(include the NE and E) of born, block the way of CA producing. express it has the axis sympathetic nerves to regulate a function.4. The born variety of the ALD and the CA presents in the circulation just related, explain both may exist mutual coordination, mutual relation for promote. |
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