| AIM:To investigate the association of insulin resistance(IR) and nonalcoholic fatty liver disease (NAFLD) in molecular mechanism state by study the relationship of their correlation factors SOCS-3 and SREBP-1c.METHODS:Establish the rat model of NAFLD, and limit the food of some rats after then. Detect the expression of mRNA of SOCS-3 and SREBP-1c in the liver by reverse transcription and polymerase chain reaction (RT-PCR). Meanwhile observe the pathological changes of the liver.RESULTS:The lever of TC, TG and HOMO-IR was significantly higher in high fat group than in controls (P <0.05), expression of hepatic SOCS-3 and SPEBP-1c mRNA were significantly up regulated in high fat group compared with that in the controls (P <0.05). The parameters were down regulated when calorie limited.CONCLUSION:IR and NAFLD are affected by diet. IR and NAFLD could be connected by some factors. |
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