The Influence Of C-reactive Protein After Plasma Radiofrequency Ablation In Patients With Obstructive Sleep Apnea Hypopnea Syndrome

Objective: 1To discuss whether surgical treatment of obstructive sleep apnea hypopnea syndrome (OSAHS) has an impact on C-reactive protein (CRP) level. 2To evaluate the short-time effect of surgical treatment on obstructive sleep apnea hypopnea syndrome and the application of plasma radio frequency ablation.Methods: 52 patients with OSAHS confirmed by PSG were selected as subject group. Serum CRP levels were evaluated preoperatively and 3 months postoperatively.Results: 1 52 patients with OSAHS, in accordance with the PSG results, included 9 mild,16 middle 27 serious. 12 cases of defaulting and 4 cases serum CRP> 10mg / L were excluded from the trial. All these 36 cases were reevaluated with polysomnography (PSG) by the end of postoperative period lasted for 3 month. Among them 6 were cured, 10 were seen with significant therapeutic effect, 17were with effective outcome, and 3 were not effective, with a total effective rate of 91.67 %. All the patients have no serious postoperative complications after surgical treatment. Also, Snoring Scale and Epworth sleeping Scale were significantly decreased after surgical treatment.2 36 cases of patients with preoperative levels of CRP were significantly decreased (preoperative 3.07±1.48mg/L to postoperative 1.57±1.03mg/L , P <0.005) after surgical treatment of plasma radiofrequency ablation three months. In the patients, postoperative AHI decreased from 49.8±13.2 to 25.6±10.7 , and LSAT increased from 80.2±7.4% to 87.9±6.8%.These values were significantly different (P<0.05).3 Even in the patients who did not achieve complete"cure"by classical PSG criteria (according to standard, 2002, Hangzhou), postoperative AHI decreased from 54.3±13.2 to 32.4±9.7, and LSAT increased from79.8±5.7% to 79.8±5.7%.The CRP level in this group decreased from3.34±1.37mg/L to1.79±1.24mg/L. There was no significant difference in CRP level change (improvement) between the success and the failure group (P=0.975).4 We evaluated the correlations between preoperative and postoperative CRP levels and PSG indexes of OSAHS in patients with moderate/severe disease. We found CRP levels is significant positively correlated with AHI (preoperative Pearson's P= 0.042; postoperative Pearson's P=0.018), and negatively correlated with LSAT (preoperative Pearson's P= -0.032; postoperative Pearson's P= -0.025).Conclusion: surgical treatment can effectively decrease serum levels of CRP in patients with 0SAHS. Therefore, surgical treatment may be useful in reduction of CRP levels in patients who will not or cannot accept CPAP therapy. And comparing the traditional surgical treatment, plasma radiofrequency ablation has the advantages of mild lesion, less bleeding, less painful and simple operation.