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Differentiation Stages Of Clinical Research In Treatment Of Cerebral Infarction

Posted on:2010-11-11Degree:MasterType:Thesis
Country:ChinaCandidate:H M QiaoFull Text:PDF
GTID:2144360275969777Subject:Traditional Chinese Medicine
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Objective: Cerebral infarction (CI), also known as cerebral infarction, is the generic name of cerebral ischemic stroke, including cerebral thrombosis , lacutypingar infarction and cerebral embolism, etc.About 70% of all stroke, cerebral blood supply is caused obstacles ischemia,hypoxia, resulting in limitations of ischemia braian tissue necrosis or encephalomlacia .Stroke mortality and disability is still very high and their treatment is very complex and difficult,especially on the most common clinical ischemic stroke (cerebral infarction). The rapid development of neuroscience, in particular images, molecular biology techniques, so that the basis of cerebrovascular disease and significant progress in clinical research, deepen the understanding of stroke pathophysiology, greatly improve the diagnosis and wide treatment of the inquiry, and achieved remarkable results.Our use of the method of Integrated Traditional and Western Medicine diagnosis of cerebral infarction clear differentiation of the phased treatment, combined Chinese and Western Medicine to explore the clinical effect of cerebral infarction, in order to effectively provide a new method and new thinkingof treatment of cerebral infarction.Method: The 109 cases of CI are selected from hospitalized patients in the Second Hospital of Hebei Medicine University.They are randomly divided into treatment group 53 cases, 56 cases of the control group. Treatment group at the basis of conventional Western medicine treatment with Chinese herbal medicine added up, control group with conventional Western medicine treatment, do not add for use of proprietary Chinese medicines, observation for four weeks. Four weeks after the assessment of efficacy,observation of neurological deficit scores,Barthel Index score,Change fibrinogen,And elements of TCM Change.Result: (1)Treatment group and control group before and after the treatment efficacy of neurological deficit scores compared: A total of 53 cases of treatment group one of 13 cases cured(24.53%),31(58.49%) cases of markedly,6(11.32%) cases of progressive, no change Example 2(3.77%), deterioration of Example 1(1.89%).The total effective rate was 94.34%。A total of 56 cases of control group,one of 10 cases cured(17.86%), 24(42.86%) cases of markedly, 12 (21.42%) cases of progressive ,example 8(14.29%) no change, deterioration in 2(3.57%)cases。The total effective rate82.14%。Significant difference between two groups P<0.05。(2) Treatment group and control group before and after treatment in neurological deficit scores compared( X±s):Treatment group before treatment the neurological deficit scores19.491±8.534,after treatment 8.830±7.605,before and after treatment significantly P<0.01.Pre-treatment control group, neurological deficit scores19.339±8.795,after treatment12.179±9.506,before and after treatment significantly P<0.01.Treatment group before the neurological deficit scores with the control group pre-treatment neurological deficit scores compared no significant difference P>0.05; After treatment, neurological deficit scores with the control group, neurological deficit scores a significant difference P<0.05。(3)Treatment group and control group before and after treatment Barthel's index( X±s) :Treatment group before treatment the Barthel index31.42±18.69, after treatment66.60±18.65,before and after treatment significantly P<0.01。Control group before treatment Barthel Index31.70±18.81,after treatment52.68±22.92,before and after treatment significantly P<0.01。Treatment group before treatment the Barthel Index and the control group before treatment Barthel's index have no significant differenceP>0.05; After treatment, the treatment group Barthel's index with the control group significantly P<0.01。(4)Treatment group and control group before and after treatment compared fibrinogen(X±s):The treatment group pre-treatment fibrinogen values6.14±1.10, after treatment5.11±0.72,before and after treatment significantlyP<0.01.Control group pre-treatment fibrinogen values5.998±0.98, after treatment5.77±0.87, before and after treatment have no significant difference P>0.05。The treatment group pre-treatment fibrinogen values with the control group have no significant difference P>0.05; After treatment, the treatment group fibrinogen values with the control group values significantly different P<0.01。(5)Treatment group and control group before and after treatment TCM Change elements. Wind permit the emergence of the trend rate decreased gradually. Treatment group before treatment the occurrence of wind syndrome92.45%, after treatment32.075%;Control group pre-treatment 91.07%, after treatment32.14%.The two groups showed a gradual downward trend, comparing the two groups no significant difference, P>0.05; Permit the emergence of the rate of fire-heat treatment group at pre-treatment64.15%, after treatment41.51%; The control group at pre-treatment 57.14%, after treatment75.00%,comparing the two groups after treatment were significantly different, P<0.05 ; Sputum permit the emergence of the rate of treatment group at pre-treatment56.60%, after treatment45.28%. The control group at pre-treatment 48.21%, after treatment80.36%, comparing the two groups after treatment there is significant difference P<0.05。Stasis Syndrome of occurrence of the treatment group at pre-treatment30.19%, after treatment24.53%. The control group at pre-treatment 26.79%, after treatment32.14%,comparing the two groups before and after treatment no significant difference, P>0.05; Asthenic yin and predominant yang's emergence rate of the two groups before and after treatment showed a lower level, after treatment than before treatment there is an upward trend, comparing the two groups no significant difference, P>0.05。Conclusion: (1)Dialectical phases in treatment of cerebral infarction treatment group the total effective rate was 94.34%,significantly higher than control group 82.14% (P<0.05).Neurological deficit scores,improvement in Barthel Index,treatment group were better than the control group (P<0.05).Treatment of cerebral infarction in phases that have better clinical efficacy(2) After staging the dialectical treatment of cerebral infarction, blood levels of fibrinogen in treatment group was significantly lower than control group. Help phases used in traditional Chinese medicine treatment of cerebral infarction can reduce blood levels of fibrinogen(3) Differentiation stages can reduce the treatment of acute cerebral infarction in patients with sputum certification card and the incidence of fire-heat, to improve the patient's functional status conditions conducive to recovery.
Keywords/Search Tags:Cerebral infarction, Chinese and Western Medicine, Efficacy, Staging, Differentiation factor
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