| Objective: Guillain - Barre syndrome (Guillain-Barre syndrome, GBS), also known as acute inflammatory demyelinating polyneuropathy, is a peripheral nerve and nerve root demyelination and small perivascular lymphocyte and macrophage inflammatory reaction for the pathological features of autoimmune disease. Clinical manifestations in flaccid paralysis of the limbs to the main symmetry can be associated with limb abnormalities and autonomic sensory barriers. Regular application of the early pathogenesis of immune globulin, plasma exchange therapy, but very expensive, and plasma exchange may have serious adverse reactions, so the main clinical use of symptomatic treatment. GBS should be based on clinical manifestations of Chinese medicine, "atrophy disease" category. Its treatment of Chinese medicine has a wealth of clinical experience. In order to exert the advantages of Chinese medicine, we have embarked on the treatment of GBS in phases dialectical studies on the treatment of GBS dialectical phases of clinical efficacy.Method: Guillain - Barre syndrome cases of the second selection for the Hebei Medical University Hospital from July 2007 to December 2008 patients 63 cases, in line with the Editorial Board of Chinese Journal of neurology and psychiatry in 1993 on the diagnostic criteria set by GBS, At less than two weeks duration. Randomly divided into treatment group 35 cases, 28 cases of the control group, treatment group, routine treatment of western medicine in phases on the basis of diagnosis and giving of treatment-free oral decoction of Chinese medicine; the control group using only conventional treatment of western medicine. Patient-patient treatment at 4 weeks after their TCM Syndrome score, activities of daily living (ADL), Hughes functional evaluation, assessment of sensory function, neuro-electrophysiology target, treatment efficacy evaluation of various indicators.Result:1 TCM Syndromes points:Integral treatment group before treatment 15.6±5.26, after treatment score 6.89±2.13; control group pre-treatment score 16.07±6.23, after treatment score 8.86±3.42. Between the two groups after the treatment group compared with the significant difference (P <0.05), prompt treatment group than the control group.2 Activities of daily living assessment:Treatment group before the index 45±15.866, after the index treatment of 76.333±14.735; the control group before treatment index 37.667±14.665, after the index treatment of 67.333±15.354. Between the two groups after the treatment group compared with the significant difference (P <0.05), prompt treatment group than the control group.3 Hughes functional evaluation:Treatment group before treatment 3.7333±0.6397, after 2.0000±0.5872; the control group before treatment 3.7333±0.5208, after 2.3000±0.5350. Between the two groups after the treatment group compared with the significant difference (P <0.05), prompt treatment group than the control group.4 Assessment of sensory function:Treatment group before treatment 1.87±0.85, after treatment 0.90±0.84; control group before treatment 1.9±0.84, after treatment 1.47±0.82. Between the two groups after the treatment group compared with the significant difference (P <0.05), prompt treatment group than the control group.5 Efficacy Evaluation:Foue weeks after treatment the treatment group accounted for two cases of invalid 5.71 percent, accounting for 8 cases of improvement of 22.86%, effective 20 cases accounted for 57.14%, accounting for 5 cases of recovery 14.19%, the total effective rate 94.29%; control group, six cases of invalid accounts 21.43%, improved 10 cases accounted for 35.71%, effective 11 cases accounted for 39.29 percent, recovered 3.57 percent accounted for Example 1, the total effective rate 78.59%. After X2 test, X2 = 6.7 p = 0.0097 <0.05, statistically significant, suggesting that the treatment group and control group were significantly different, and the total treatment group have higher efficiency. 6 Neuroelectrophysiological Detected6.1 Motor nerve conduction results:Treatment group the median nerve, ulnar nerve, peroneal nerve, after treatment of distal latency, motor nerve conduction velocity, distal compound muscle action potential amplitude, the indicators are better than before treatment; the control group in addition to the ulnar nerve, the median nerve, peroneal nerve, after treatment of distal latency, motor nerve conduction velocity, distal compound muscle action potential amplitude, the indicators are better than before treatment.After treatment of median nerve distal latency, motor nerve conduction velocity, distal compound muscle action potential amplitude, the treatment group were better than the control group; ulnar nerve distal latency in addition to, the motor nerve conduction velocity, distal compound muscle action electric bit amplitude, the treatment group were better than the control group; peroneal nerve distal latency, motor nerve conduction velocity, distal compound muscle action potential amplitude, the treatment group were superior to the control group.6.2 Sensory nerve conduction results:After treatment of median nerve sensory nerve conduction velocity, the treatment group than the control group. Other neurons no significant difference.Conclusion:1 Guillain - Barre syndrome in phases dialectical treatment period, the total effective rate was 94.29%, significantly higher (<0.05); through the activities of daily living before and after treatment assessment, Hughes functional evaluation, assessment of sensory function, the indicators are better than the control group. Guillain - Barre syndrome dialectical phases of treatment with good effect.2 GBS through determination of target neuroelectrophysiolog- ical showed distal motor latency, motor nerve conduction velocity, compound muscle action potential amplitude, sensory nerve conduction velocity changes in the indicators are better than the control group. That used in the treatment of GBS phases of Chinese medicine can improve the function of peripheral nerve conduction.3 Before and after treatment by TCM Syndrome points to improve the situation showed that the treatment group was significantly better than the control group. Treatment of GBS in phases that can improve the functional status of patients with the body will help restore the condition. |
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