| The first departmentObjective: To observe the clinical curative effect of treating constipation predominant irritable bowel syndrome with Jiawei Erzhi Jian and the influence of quality of life.Method: The case-control study was adopted. The selected cases according to"Randomized Number Scale"were randomly divided into two groups: 40 patients in treatment group were administered with Jiawei Erzhi Jian; 40 patients in control group were administered with Compound prescription aloe capsule. Both groups were treated for four weeks. Clinical symptoms'changes, effect on quality of life before and after treatment were detected respectively to evaluate the therapeutic effects.Result:(1)Clinical symptom therapeutic effect: In treatment group the total efficiency is 87.50%,which is no significantly difference than that of control group(P>0.05).In control group the total efficiency is 84.21%. (2) Compared the main clinical symptom before and after treatment: After treats 2 weeks,all the main clinical symptoms were improved after treatment in treatment group(P<0.05), while only bowel movement character, bowel movement difficulty, distension of the abdomen and abdominal pain were improved after treatment in control group (P<0.05); After treats 4 weeks , all the main clinical symptoms were markedly improved after treatment in treatment group(P<0.01), and after also treats 2 weeks to have the difference (P<0.05) before, but the control group various symptoms treat have the improvement (P<0.05), but after treats 2 weeks the difference not to be remarkable. There was a significantly difference between treatment group and control group after treatment in bowel movement character, abdominal pain, bowel movement difficult, energetic aspect(P<0.05). (3) Compared the observation indexs of quality of life before and after treatment: After treatment two group of quality of life integral compared to before treatment remarkable improvement, has the remarkable different significance (P<0.01 or P<0.05 ) (4)Compared prostecdtive efficacy:The recurrence rate in treatment group was 9.4% while in control group was 36.7%.There was a significantly difference between two groups(P<0.05).(5)Evaluate therapeutic safety in the two groups: There were neither obvious changes in blood, urine or stool rules before and after treatment nor in Electrocardiogram or liver-renal function. In the course of the treatment, all patients had no undesirable response, which pointed the fact that treatment group and control group have no toxic and side effect.Conclusion: The study indicates that Jiawei Erzhi Jian can improve patient's clinical symptom, sublimate quality of life, decrease the recurrence rate of constipation predominant Irritable Bowel Syndrome. Its curative effect is better than that of Compound prescription aloe capsule. The research from clinical curative effective aspect approves that Jiawei Erzhi Jian is feasible and practicable in treating constipation predominant Irritable Bowel Syndrome.The Second DepartmentObjective: To explore mechanism of Jiawei Erzhi Jian in treating constipation predominant irritable bowel syndrome by constructing animal model.The aim is to provide experimental evidence for clinical research.Method: 40 healthy half and half female and male Wistar rats were selected and randomly divided into five groups:normal group, Cisapride group, model group ,Compound prescription aloe capsule group, traditional Chinese medicine treatment group , each group had 8 rats. Besides the normal group, other each group of rats use method of the ice water to fill the stomach law to make rat models of constipation predominant irritable bowel syndrome . After making the mold succeeds, the second day to start to treat: the amount of dried medicinal herb given to traditional Chinese medicine treatment group was 27.3g/kg weight . The amount of Cisapride given to Cisapride group was 30mg/kg weight. The amount of Compound prescription aloe capsule given to Compound prescription aloe capsule group was 20mg/kg weight. The normal saline was given to normal group and model group, respectively.Each group continuously fills the stomach 14 days. Excrement number of seeds and water content, body weight change were observed before and after treatment. After end time for medicine, fasts to be unable to restrain the water 10 hours, Two weeks later ,50% charcoal suspension lavaged, all rats were killed to observe following index after 20 min:small intestine charcoal suspension pushing rate,vasoaction intestinal ploypeptide(VIP),substance P(SP), pathology of bowel mucosa tissue.Result:(1) Compared excrement number of seeds and water content before and after treatment: excrement number of seeds and water content before one day treatment in model group,Cisapride group, Compound prescription aloe capsule group, traditional Chinese medicine treatment group was markedly lower than that of normal group(P<0.01).After fourteen day treatment in traditional Chinese medicine treatment group was markedly higher than that of Cisapride group(P<0.01) ,but it and compound prescription aloe capsule group was no significant difference(P>0.05),(2) The change in body weight: Compared with normal group,the body weight of other rat groups was all weiht after model (P<0.01).Compared with normal group, the body weight of model group was markedly weight after treatment (P<0.01). There were no significantly difference among the rest groups.(3)Compared the small intestine charcoal suspension pushing rate:Compared with normal group, model group,Cisapride group and compound prescription aloe capsule group could decrease charcoal suspension pushing rate(P<0.01), especially model group. There were no significantly difference between traditional Chinese medicine treatment group and normal group.(P>0.05) (4) The contents of VIP in colon mucous membrane organization: Contents of VIP in Cisapride group and compound prescription aloe capsule group and traditional Chinese medicine treatment group was markedly increased than that of model group, especially traditional Chinese medicine treatment group. (5) The contents of SP in Small intestine mucous membrane organization : Contents of SP in traditional Chinese medicine treatment group and compound prescription aloe capsule group was markedly increased than that of model group(P<0.01). Compared with Cisapride group, traditional Chinese medicine treatment group could significant increase the Contents of SP (P<0.05). (6)Observation of bowels mucosa tissue:The bowels mucosa tissue of rats was not found apparente inflammatory pathological changes。Conclusion: The mechanism of Jiawei Erzhi Jian in the treatment of IBS was to adjust the disordered secretion and release of gastrointestinal hormones,such as VIP, SP...
|
PDF Full Text Request