5Hydroxytryptamine Is In The Measurement In The Congenital Heart Attack And The Clinical Meaning

Purpose:The congenital heart attack(CHD) is rightwards particularly left reposition of redundant personnel type first secret concern, shear to slice increasing of dint and pressure Gao and cause skin function inside the blood vessel and the change of structure because of the lung blood vessel part, and have no muscle cell the muscle turn or the muscle artery muscle the layer increase thick.The pulmonary artery high pressure(PAH) is 1 kind to be taken place to any age of latent cause death a sexually transmitted disease to change, mean pulmonary artery the constringency presses>25 mmHg(rest) or>30 mmHg, and usually the companion have pulmonary artery to press on the average of go up.Is familiar congenital heart attack complic- ations, various PAH has same pathology change and the clinical performance of likeness and is taken bad a mechanism to involve cell, body fluid member and genetics level.If PAH can not get a control in time, finally will cause right heart function's crocking up, even in first secret concern surgical operation hereafter cause the pulmonary afferent resistance to sharply go up, cause the pulmonary artery high pressure crisis and the low heart row comprehensive disease, how the biggest degree ascend prevention and the treatment lung artery high pressure to have become relation first secret concern the sufferer exist the quality and surgical operation key after preparing. Relevant 5Hydroxytryptamine An and lung arteries the high pressure is taken bad a mechanism of research, a lot of foreign scholars testing and leaving in the animal has already confirmed in the body lung artery blood vessel 5Hydroxytr yptamine the An is a kind of afferent constringency factor and urge the afferent and smooth muscle has the silk abruption, but relevant 5Hydroxytryptamine An at pulmonary artery high pressure the sufferer is inside the body of distribute and it with the pulmonary artery high pressure condition development of relation of research fresh have a report of way.This experiment passes to examine the different type congenital heart attack of patient blood plasma in 5Hydroxytryptamine level of distribute, variety with front and back surgical operation, analyze 5Hydroxytryptamine relationship with congenital blood dyna mics index sign, explain by period 5Hydroxytryptamine with first the relation of the secret concern pulmonary artery high pressure, evaluate5 Hydroxytryptamine 's diagnosis and the function in the condition valuation in lung artery high pressure, try for pass to repress 5Hydroxytryptamine treatment lung artery high pressure of the possibility find out clinical basis.Method:Sieve heart surgery hospitalization in my hospital of 30 first the secret concern building room lacks to suffer from son, while depending on a quiet interest pulmonary artery pressure>the 25 mmHgs(super voice) is divided into the lung artery high pressure set and the non- pulmonary artery high pressure set.All pressures(PASP) that suffer from son to hospitalize to move to measure lung artery with the super voice behind, lung artery width, left, the right room horizontal path, the EF is worth.Be moved by, the vein takes a blood(avert from an infection to expect and useβ-tT) back up and does guts analysis to measure PO2, SO2 respectively and use the Mao allied immunity method respectively after hospitalizing 24 hours and Shu behind stop a machine to ventilate and stop using for 24 hours after the vein afferent and live medicine, measurement moves, vein blood plasma 5Hydroxytryptamine.Two sets of the differences that suffers from son after hospitalizing 24 hour, avert from an infection period and use afferent and live medicine(if theβ-tT), Shu behind stop usage after the vein afferent and live medicine and measure pulmonary artery for 24 hours, the constringency presses, the lung artery width, the left and right room horizontal path and EF value, take to take the upper level blood plasma to used for measuresing after moving, the vein blood the difference place an EDTA tube to leave heart in the meantime co5Hydroxytryptamine ntent, and take artery blood to do guts analysis in the meantime, measurese PO2, PCO2 and SO2.Measurese its machine to ventilate time after Shu in the meantime, ICU observes time and the vein afferent and live medicine usage time learn by having a statistics data analysis usage.Result:First the secret concern pulmonary artery high pressure suffers from son before the Shu artery blood plasma in 5Hydroxytryptamine density a little bit first the secret concern has no lung artery high pressure set to suffer from son artery blood plasma in 5Hydroxytryptamine obviously goes up;(P=0.000)First the secret concern pulmonary artery high pressure set ex- the Shu artery blood blood plasma 5 to compare with its vein, the 5Hydroxytryptamine density blood in of is Gao(P=0.003), but first secret concern have no the pulmonary artery high pressure set the action vein blood blood plasma 5Hydroxytryptamine density then has a contrary circumstance with the pulmonary artery high pressure set, vein blood blood plasma 5Hydroxytryptamine density is higher than its artery blood in of density(mean:1.1659|0.9710);(P=0.000)First the secret concern lung artery high pressure set surgical operation front and back artery blood blood plasma 5Hydroxytryptamine density the variety have a statistics to learn meaning, P=00000, after operation lower before comparing surgical operation:First the secret concern lung has no artery high pressure set surgical operation front Empress artery blood blood plasma 5Hydroxytryptamine density the variety as well have a statistics to learn meaning, P=00000, after operation lower before comparing surgical operation, but compare the lung artery high pressure set lower range to have to be small;First the secret concern lung artery high pressure set the surgical operation front and back vein blood 5Hydroxytryptamine surgical operation the variety has a statistics to learn meaning(P=0.0000) before or after, the Shu turns down a little bit before the Shu behind;But have no lung artery high pressure set surgical operation before or after the variety has no statistics to learn meaning; (P=0.053)The lung artery high pressure set with have no lung artery high pressure set surgical operation before or after the variety all has a statistics to learn meaning(p=0.000), but shows Zhao by the lung artery high pressure set variety, and the lung artery high pressure set artery blood in 5Hydroxytryptamine density and lung artery pressure contain related better straight line relation, but have no the lung artery high pressure set then can not build up a good and related relation;The lung artery high pressure set surgical operation front and back artery blood oxygen cent pressed variety to have a statistics after learning the meaning(P=0.032) Shu to have an obvious improvement a little bit before the Shu;And before the Shu the lung artery high pressure set with have no lung artery high pressure set, normal artery to learn oxygen to press to compare it for cent total all count obviously low, hint5Hydroxytryptamine the density go up to have relation with low oxygen in the circulation;The lung artery high pressure set(P=0.000) has no the surgical operation front and back lung artery width variety of lung artery high pressure set(P=0.001) to all have a statistics to learn meaning and hints that the of change and 5Hydroxytryptamine releasing of Ans and the absorption of lung artery structure exists correlation;Examine 5Hydroxytryptamine previously secret concern blood circulation system in of the variety can be better to explain 5Hydroxytryptamine and the pulmonary artery high pressure course of illness evolve of relation, take expecting as first diagnosis and treatment of the secret concern lung artery high pressure to provide theories basis and clinical clues.Conclusion:congenital heart patient son circulation in 5Hydroxytryptamine the density of the An compare of an age set the normal child shows increased, first the secret concern pulmonary artery high pressure set suffer from son artery blood in 5Hydroxytryptamine density compare have no the pulmonary artery high pressure set obviously go up and along with pulmonary artery pressure of go up but go up and present straight line related relation;Surgical operation hereafter first the secret concern suffer from son circulation in 5Hydroxytryp- tamine the density of the An obviously descend, the pulmo -nary artery pressure also has to obviously descend.The pulmonary artery width that 2 sets measures, the or so room horizontal path, EF value and artery blood oxygen cent presses although not ability with5Hydroxytryptamine of establishment straight line related relate to, the surgical operation all has better improvement before or after.The originally clinical research shows: 5Hydroxytryptamine is a kind of body fluid factor with first the occurrence of the secret concern lung artery high pressure and develop germane, pass a rightness first the secret concern suffer from son to carry on 5Hydroxytryptamine metered examination diagnosis and the valuation lung artery high pressure of the An and pass to repress5Hydroxytryptamine treatment lung artery high pressure worth study.