Research Progress In GLP-1 Analogues With Type 2 Diabetes Mellitus And Its Chronic Complications

GLP-1 is an incretin hormone secreted from enteroendocrine L cells and pancreatic cells in response to ingested nutrients.physiological functions include increaseing insulin secretion from the pancreas in a glucose-dependent manner,decreaseing glucagon secretion from the pancreas,increaseing beta cells mass and insulin gene expression,inhibiting acid secretion and gastric emptying in the stomach,and decreasing food intake by increasing satiety.But it is rapidly inactivated by the enzyme dipeptidyl peptidaseâ…£(DPP-â…£),which greatly limits its clinical application.GLP-1 analogs overcome the disadvantage of short T1/2 of GLP-1,and give the treatment for diabetes a new opportunity.DPP-â…£inhibitors inhibit the degradation of GLP-1.It has been demonstrated recently that GLP-1 analogues and DPP-â…£inhibitor play a protective role in the circulatory system and nervous system,These observations may subject to results of future studies translate into improved cardiovascular and neuval outcomes in this vulnerable patient population.Exenatide,as a first approved GLP-1 analogues,has conducted a large number of clinical trial.This article summarizes current concepts of GLP-1,s action and highlights the potential therapeutic utility for the treatment of Diabetes mellitus and its chronic complications.