Research Of The Relationship Between ER,PR And Prognosis Of Colorectal Cancer

Objective: To detect the expression of ER and PR in colorectal cancer tissue, study their relations with the main clinic pathological characteristics and prognosis of colorectal cancer, try to provide a reference for the clinical diagnosis, assessment of prognosis, as well as the endocrine therapy of colorectal cancer.Methods: Retrospectively inspect the expression of ER, PR of 171 colorectal cancer tissues from patients undergoing radical surgery in Guangxi Medical University Cancer Hospital from January 1st, 1998 to December 31st, 2003, and analyze their relations with the patients'corresponding clinical data, especially the five-year survival rate.Results: (1)The positive expression rate of ER and PR is 80.7%,and 73.7%, respectively. (2)The expression of ER and PR is positively correlated significantly. (3) The expression of ER is negatively correlated with tumor's histological grade, depth of invasion, and Dukes' stage; The expression of PR is negatively correlated with tumor's lymph node metastasis, distant metastasis, Dukes' stage. (4)Patients with positive ER, PR have a significantly higher 5-year survival rate than ER, PR-negative patients, and the rate has an upward trend with the ascension of the expression of ER. (5)There is no correlation between the expression of ER and age, sex, primary tumor site, tumor size, gross pathologic type, histological type, lymph node metastasis, distant metastasis, or preoperative CEA expression. PR has no significant correlation with patients'age, sex, primary tumor site, tumor size, gross pathologic type, histological type, histological grade, depth of invasion, or preoperative CEA expression. (6)Cox proportional hazards regression model analysis shows that: pathology gross type, histological grade, lymph node metastasis, distant metastasis is the risk factors of prognosis colorectal cancer patients,but ER is the protective.Conclusion: The higher the ER expresses, the better the prognosis of patients is. Most of the colorectal cancer is hormone-dependent. Detection of ER, PR expression contributes to the clinical diagnosis and prognosis assessment of colorectal cancer, and provides a basis for its endocrine therapy.