| Objective To evaluate the value of strain rate imaging(SRI) in detecting the relationship between the thoracic Radiotherapy-induced myocardial damage and the dose of the Radiotherapy and the clinical value in thoracic radiotherapy-induced myocardial damage by studying the characteristics of strain rate in the left ventricular walls.Methods SRI and conventional echocardiographic parameters were performed in 40 patients with thoracic radiotherapy.According to the process of radiotherapy,the patients were divided into five groups:group A:1 - 2 days before the radiation treatment;group B:radiotherapy time was 3 weeks,radiotherapy dose was 30 Gy;group C:radiotherapy time was 4 weeks,radiotherapy dose was 40 Gy.group D:radiotherapy time was 5 weeks,radiotherapy dose was 50 Gy.group E:radiotherapy time was 6 weeks, radiotherapy dose was 60 Gy.SRI was obtained through the apical window in chamber and long apical views to measure s(systolic strain rate),e(early diastolic strain rate),a (later diastolic strain rate) respectively.Result s,e of group D,E in anterior wall,anterior septum,posterior wall were significantly lower than those in group A(P＜0.01);s,e of group B,C in anterior wall,anterior septum,posterior wall were lower than those in group A,which had no significant difference(P＞0.05);s,e of anterior wall,anterior septum,posterior wall in B,C,D,E groups had no significant difference(P＞0.05);s,e of inferior wall, posterior septum,lateral wall in all groups had no significant difference(P＞0.05).Left ventricular diastolic function(E/A) of group D,E was significantly lower than that in group A(P＜0.01);There was no significant difference of E/A between group B,C and group A(P＞0.05). Conclusions Radiotherapy-induced myocardial damage appear,when the dose of the thoracic Radiotherapy≥50Gy,SRI can quantitatively detect myocardial damage in patients with thoracic radiotherapy. |
PDF Full Text Request