| Objective: This study examined the alteration of integrated backscatter (IBS) and the indexes of cardiac structure and cardiac function in early thoracic radiotherapy-induced myocardial damage. The aim of this study was to evaluate the diagnostic value of acquisition densitometry in detecting early thoracic radiotherapy-induced myocardial damage.Methods: IBS and conventional echocardiographic were performed in 40 patients with thoracic radiotherapy. According to the process of radiotherapy and position of radiotherapy, The patients were divided into three groups(40, 16 and 24 patients in groups A, B1, B2 respectively), group A: before the radiation treatment(control group); group B1: after the radiation treatment(irradiated from prothorax, not got to metathorax); group B2: after the radiation treatmen(tirradiated from pro-to metathorax). Using a color doppler ultrasound system with AD-IBS soft ware (Agilent Sonos 5500), normalized IBS (IBS%) and peak to peak intensity (CVIB) and standard deviation intensity (SDI) were obtained at Parasternal Left Ventricular Long Axis View, Short Axis View of the Level of Papillary Muscle of Left Ventricular and the indexes of cardiac structure(such as IVSTd, LVDd, LVPWTd, LADs etc) and cardiac function (such as EF%, FS%, E/A etc)were examined in for groups at the same time.Results: (1) IBS% changed periodically in each subjects of before the radiation treatment and after the thoracic radiation treatment , and the valuewas maximal at end diastole and minimal at end systole. (2) IBS% in group B1, the anterior wall, anterior septum were significantly higher than those in group A(P<0.01); CVIB were significantly lower than those in group A(P<0.01), IBS% in group B2, the anterior wall, anterior septum and posterior wall were significantly higher than those in group A(P<0.01); CVIB were significantly lower than those in group A(P<0.01). (3) IBS%, CVIB in group B1, the inferior wall and posterior wall, and in group B2, the inferior wall compared with those of group A had no significant difference(P>0.05); IBS% in group B2, the posterior wall were significantly higher than that in group B1(P<0.01); CVIB were significantly lower than that in group B1(P<0.01), IBS%, CVIB in group B1, the anterior wall, anterior septum , inferior wall compared with those of group B2 had no significant difference(P>0.05). (4) No significant difference of SDI were found in three groups. (5) LADs, LVDd, IVSTd, PWTd, EF%, FS% and echo of myocardial were compared with among three groups had no significant difference(P>0.05); E/A in group B1 and group B2 were significantly lower than that in group A(P<0.01); E/A in group B1 compared with group B2 had no significant difference (P>0.05).Conclusions: IBS% of after the thoracic radiation treatment were significantly higher than the patients of before the radiation treatment and CVIB were significantly lower than the patients of before the radiation treatment, IBS can indicate the change of heart disease in pathology and be value of systolic function in the examination. IBS is valuable to assess early thoracic radiotherapy-induced myocardial damage. IBS is a nonvasive and valuable method to assess early thoracic radiotherapy-induced myocardial damage.Objective: There is evidence that Strain Rate Imaging(SRI) can quantitatively evaluate the function of ventricle wall motion. Tissue Tracking(TT) can calculate the systolic displacement of myocardial of left ventricle to the apex. The aim of this study was to evaluate the value of SRI and TT in detecting early thoracic radiotherapy–induced myocardial damage by using SRI to analysis the characteristics of left ventricle wall and TT to measure the systolic displacement of left ventricle wall .Methods: SRI and TT were performed in 40 patients with thoracic radiotherapy. The patients were divided into three groups(40 patients in groupsA,B,C respectively): group A: before the radiation treatment(control group); group B: radiotherapy time was 2.5～3 weeks, radiotherapy dose was 26～30Gy; group C: radiotherapy time was 5～6 weeks, radiotherapy dose was 50～60Gy. Using a color doppler ultrasound system with SRI and TT soft ware (GE Vivid7 ), SRI and TT were obtained through the apical window in 4-chamber ,2-chamber and long apical views to measure systolic strain rate (s), early diastolic strain rate (e), later diastolic strain rate (a) and displacement of systolic respectively.Results: SRI: (1) s, e of group C in anterior wall, anterior septal and posterior wall were significantly lower than those in group A(P<0.01); s, e of group C in anterior wall, anterior septal and posterior wall were lower than those in group B(P<0.05); s, e of group B in anterior wall, anterior septal and posterior wall compared with those in group A, had no significantly difference (P>0.05); (2) a in all groups, s, e of left lateral wall, posterior septal and inferior wall in all groups had no significantly difference (P>0.05). TT: (1) Systolic displacement of group C in anterior wall, anterior septal and posterior wall were significantly lower than those in group A(P<0.01); Systolic displacement of group C in anterior wall, anterior septal and posterior wall were lower than those in group B(P<0.05). (2) Systolicdisplacement of group B in anterior wall, anterior septal and posterior wall compared with those in group A, had no significantly difference(P>0.05); Systolic displacement in left lateral wall, posterior septal and inferior wall had no difference among three groups respectively(P>0.05).Conclusions:The parameters of SRI and TT after the thoracic radiation treatment were significantly lower than those in the patients of before the radiation treatment , SRI and TT can indicate the change of heart disease in function of systolic and diastolic. SRI and TT are valuable to assess early thoracic radiotherapy-induced myocardial damage. SRI and TT are nonvasive and valuable methods to assess early thoracic radiotherapy-induced myocardial damage.
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