| Objective:to study whether there is repair function to spinal cord injury in rats after activated microglia transplantation,to evaluate the neurological function in rats after activated microglia transplantation in order to observe the treatment results.And compare BBB scale,modified Tarlov grading, inclined plane method and motor evoked potentials test(MEPT) commonly used,to find accurate and reliable evaluation methods.Methods:We established the spinal cord injury rat models with the selfmade reformed Allen's strike equipment,randomly divided into two groups: the transplantation group and the control group.We transplanted activated microglia to the transplantation groupbut but did not transplant to the control group.The models were scored the nerve function by BBB scale in weeks 1, 2,3,4,6and10 after the transplantation operation respectively,at the same time,inclined plane method,Modified tarlov grading and motion evoked potential detection was also carried out,and statistics analysis was conducted.Results:Critical angle in incline plane test was decreased in 6 weeks(P＜0. 05),but in 10w this change disappeared(P＞0.05);Modified Tarlov grading was compared:1w,2w,3w,4w,the difference of scale was different(P＜0. 01),but in 6w and 10w this change disappeared(P＞0.05);In every week after operation,statistical significance of the distinction of BBB scale and motion evoked potential detection existed(P＜0.05).Conclusion:activated microglia transplantation can promote the recovery of the nerve function in SCI rats;for these different neurological evaluation methods,BBB scale and motion evoked potential detection have more advantages.
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