Changes And Significance Of Serum Soluble Intercellular Adhesion Molecule-1 (sICAM-1) In Huge Primary Hepatocellular Carcinoma Patients Before And After Transcatheter Arterial Chemoembolization

Objective: Observing the changes of serum soluble intercellular adhesion molecule-1 (slCAM-1) in patients with huge primary hepatocellular carcinoma (PHC)before and after transcatheter arterial chemoembolization(TACE), it was investigated to identify the clinical significance of sICAM-1 in estimating the effects of TACE and to explore the relation between sICAM-1 level and activity of the tumor. Methods: Applying TACE skill to cure 16 cases with huge PHC(tumor largest DH from11cm-17cm, 12.45士1.91cm), serum sICAM-1 levels in 14 healthy persons and patients were detected by means of enzyme linked immunosorbent assay (ELISA) before and after TACE 1 month,and after the second TACE 1 month. Results:Compared with control group(586.83士199.65)ng/ml,before the first TACE serum slCAM-1(1559.66士614.08)ng/ml in patients with PHC was significantly higher(P=0.001).There is no significant difference between different AFP groups.One month after the intervention therapy serum slCAM-1 (1000.96士282.88)ng/ml significantly decreased(P<0.001).With significant differences before and after the intervention therapy, serum slCAM-1 after the second TACE wasn't significantly higher than normal (P=0.056). Furthermore, tumor volume diminution proportion after TACE for 1 month was correlated with decrease of slCAM-l (r= 0.512,P<0.05) and the changes of slCAM-l were correlated with with AFP ( r= 0.584, P<0.05). Conclusion: It can be concluded that TACE can reduce serum sICAM-1 level in patients with huge PHC, sICAM-1 and tumor activity were closely ralated to huge PHC patients, sICAM-1 levels can help judge the opportunity of TACE and are valuable in estimating the effect after TACE, especial have a potential's advantage to those AFP are negative.