Analysis Of Traditional Chinese Medical Syndromes In Diabetic Nephropathy

ObjectiveThis exploratory study attempted to know the distribution of diabetic nephropathy on the type of syndrome.MethodThis study,utilizing cross-sectional and retrospective survey research methodsln strict accordance with the inclusive criteria,Choosed type 2 diabetes with diabetic nephropathy Patients diagnosed by four hospitals of a Third-rank first class.The four methods of examination information of Chinese Traditional Medicine and information of laboratory were collected.Firstly,these datas inputed to EpiData3.10,and then imputed to Spss11.5 for statistical analysis,type of Syndrome about TCM analysis use of cluster analysis system(Hierarchical Cluster),in the variable clustering method(Variables Cluster),combined with expert opinions to determine the representatives symptoms of each type,and summed up the common TCM type of diabetic nephropathy syndrome.Results236 cases of type 2 diabetes with diabetic nephropathy were selected,PhaseⅠdiabetic nephropathy accounted for 0,PhaseⅡaccounted for 16,PhaseⅢaccounted for 65,PhaseⅣaccounted for 144,PhaseⅤaccounted for 11, mainly in Clinical Phase.In regard of TCM syndrome,clinical manifestations of diabetic nephropathy were complex and diverse.By Frequency Statistics, in accordance with the practice,after amoving Variables whose Frequency Less than 7%got 39 terms Indicators,The results showed that the following Symptoms Frequency were the highest,More than 50%,Including mental fatigue,limb numbness,Oropharyngeal drying,drinking water increased,dark tongue. The second most common Symptoms were body fat,fuzzy things,weak,poor appetite,insomnia,more nocturnal,lower extremity edema,frequency of occurrence in more than 30%.The common type of diabetic nephropathy syndrome were deficiency heat,accounted for31.8%,Qi deficiency,accounted for 46.2%,the deficiency of Kidney-Yang,accounted for 14.8%,pure sthenia syndrome, accounted for 7.2%;Folder syndrome types as follows:Phlegm was 32.6%, wetlands was 42.4%,hematocele was 61.9%;With hematocele,deficiency heat was 32.9%,Qi deficiency was 47.3%,the deficiency of Kidney-Yang was 13.0 %,The Specific datas of Phlegm and wetlands were Listed in the text.The distribution of syndrome types was influenced by some factors,such as age,course,Phases of diabetic nephropathy.By chi-square test,the distribution of deficiency heat syndrome was not significant on different sex and age groups in statistics(P＞0.05).The course of pure sthenia syndrome,such as Phlegm and wetlands,hematocele was the shortest.From sthenia syndrome to deficiency heat,to Qi deficiency,to the deficiency of Kidney-Yang,the Course was gradually extended.By ANOVA,there were few significant differences between the overall mean(P＝0.000).Multiple comparisons showed that there were significant differences between the pure sthenia syndrome group and the other three groups(P＜0.01).There were no significant difference between the remaining three groups.By chi-square test,the distribution of syndrome types between PhaseⅢand PhaseⅣdiabetic nephropathy was not different in Statistics(P＝0.593).176 cases of 236 survey had determination of plasma fibrinogen(Fib),comparising diabetic nephropathy in stages in accordance with the standards.ANOVA showed that comparing the overall levels of Fib,among the four groups,there were significant difference in Statistics(P＜0.01) between PhaseⅢand PhaseⅣor PhaseⅤdiabetic nephropathy,between PhaseⅡand PhaseⅤ,there were significant difference(p＝0.043,0.050) between PhaseⅡand PhaseⅣ,between PhaseⅣand PhaseⅤ.The Fib ratios of PhaseⅢwere higher PhaseⅡ,but there were no difference between the two groups (p＝0.556).Fib mean of each group with the growing of classification level increased,and linear trend.Objective to compare the differences of Urinary protein,203 patients with diabetic nephropathy(DN)were divided into two groups base in deficiency of the Kidney.By T test,Urinary protein level in the two groups were significantly difference(P＜0.01).ConclusionThe common type of diabetic nephropathy syndrome clinical were deficiency heat,Qi Deficiency and the deficiency of Kidney-Yang.Among them,Qi deficiency was the most common.Phlegm and hematocele throughouted the entire course of diabetic nephropathy.The distribution of deficiency heat syndrome was not significant on different sex and age groups.From sthenia syndrome to deficiency heat,to Qi Deficiency,to the deficiency of Kidney-Yang,The course is gradually extended.This was confirmed in the study three types of evidence-based standards in line with the disease development process,also responsed to a specific stage of DN in the course of the pathological state. Research had shown that there were significant differences among the type of diabetic nephropathy TCM syndrome in urine albumin excretion rate(UAER). As the disease progress,Fib increased significantly.The results suggested that the indicators above could be used as objective basis of TCM syndrome types.In this study used cluster analysis system(Hierarchical Cluster),combined with expert opinions to summed up the common TCM type of diabetic nephropathy syndrome,and studied out the Standardized syndromes of diabetic nephropathy.And at the same time,it expanded the discussion regarding the relations of TCM syndrome types and Fib,UAER.It provided reference about diagnosis and treatment of traditional Chinese and western medicine and scientific research for diabetic nephropathy.