Relationship Between Acne And Genes Associated With SRD5AⅡ In Han In Yunnan Province

Objective To discusses the relationship between acne and testosterone 5-αⅡoxidoreductase(SRD5A2) A49T,V89L gene,in the Han nationality of Yunnan province.Method We made genetic polymorphisms enzyme cut appraisal for V89L(89 anticodon leucine alternative valineV,L) and A49T(49 anticodon 1-threonine alternative alanineA,T) of testosterone 5-αⅡoxidoreductase(SRD5A2) by using polymerase chain reaction(PCR) - restriction fragment length polymorphism method for 236 cases acne patients and 144 healthy controls,in the Han nationality of Yunnan province.Results There is relationship between V89L alleles frequency distribution of Yunnan male severe acne patients and healthy controls population(X~2= 6.377,P = 0.012,P < 0.05).There is significant difference between Yunnan male heavy acne group LV + VV genotype patients and healthy controls crowd(X~2 = 4.498,P = 0.034,P < 0.05). There is not statistical significance between distribution frequencies of A49T and V89L alleles of Yunnan acne patients(male severe acne,female moderate acne, female severe acne) and healthy controls,(P > 0.05).There is not statistical significant between the A49T allele distribution frequencies of Yunnan male severe acne patients and healthy controls population(P > 0.05).Conclusion V89L allele(LV + VV genotype) may be the susceptibility genes of yunnan male heavy acne.