Study On The Change Of Riboflavin Status Influenced By Supplementing Different Doses Of Riboflavin In Severely Burned Patients

Objective Through observing the change of coefficient of erythrocyte glutathione reductase activity and the serum total antioxidant capacity at various time after injury in severe burned patients,who had been supplemented different doses(10mg and 30mg) of riboflavin;At the same time Recording the number of patients with lack-riboflavin-related disease,such as angular cheilitis,Cheilitis,Glossitis etc.We want to compare and analyse a more appropriate supplementary dose of riboflavin to direct the clinical nutrition treatment in severely burned patients,which could correct the lack of riboflavin status promptly.Methods 1.90 severely burned patients who were admitted to treatment in our hospital were randomly divided into three groups,supplemented groups(groupⅠ, groupⅡ)and not supplement group(groupⅢ),and each group contain 30 cases.By registerring the daily diet which verified by asking the patients and recording the quantity of riboflavin,protein and energy intake via intravenous(or oral) every day, we caculated according the Food composition table the daily total amount of riboflavin,protein and energy intake by every severely burned patients in 3-7d,8-14d,15-21d after injury.2.From the third day after injury,we begin to add riboflavin(groupⅠ10mg/d and groupⅡ30mg/d) to the supplementary groups lasting for three weeks.At the same time,we take all patients' early morning fasting venous blood separately in 3,7,14,21 day after injuried to determine the coefficient of erythrocyte glutathione reductase activity and serum total antioxidant capacity.3.Observing the number of patients with angular cheilitis,Cheilitis,Glossitis and the side effect caused by taking riboflavin in each group.Result 1.There was no significantly different in the total amount of protein and energy intaked by each patient in the same period after injury.(P＞0.05);2.During the same times after injury,the number of riboflavin-lack patients in each supplemented groups are much less than it in the non-supplemented group,and the total serum antioxidant capacity are more higher than the control group,all the differences are statistically significant(P＜0.05); 3.During 3-14 days after injury,the total serum antioxidant capacity in the supplementary groups are increasing significantly while its declining in non-supplemented group(P＜0.05);during 14-21 days,the total serum antioxidant capacity in groupⅡis much higher than it in groupⅠ,while the number of riboflavin-lack patients is obviously lower(P＜0.05).4.In the same period during 14-21 days after injury,the number of patients with lack-riboflavin-related symptoms in the groupⅢare much higher than other two groups(p＜0.05);on the other hand,the number of patients with angular cheilitis, Cheilitis,Glossitis in groupⅡis significantly less than in groupⅠ(P＜0.05).Conclusion During the first two weeks after injury the lack of riboflavin become more serious in the severely burned patients.If we could add riboflavin 30mg/d to them,there will be a great change in their riboflavin nutritional status,the number of riboflavin-lack case and incidence of lack-riboflavin-related disease will be reduced obviously,their total serum antioxidant capacity will become more and more stronger, and the healing speed of the burned wound would be improved significantly.