| ObjectiveTo study the diagnostic value of quantitative proton magnetic resonance spectroscopy(~1H-MRS) and volumetric MR(vMR) in the hippocampus of children on focal temporal lobe epilepsy(fTLE),and analysis the relationship between the volume change of the hippocampus and clinical factors.Methods3.0T ~1H-MRS and vMRI were used to study the 30 children(mean age 8.5years, 5 to 14 years) with unilateral fTLE,proven by 24 hours activeelectroencephalogram (AEEG),and 30 random healthy volunteers(mean age 8.8,age 5 to 14 years) served as controls.The spectral resonance lines of N-acetylaspartate(NAA)/creatine(Cr) and volume of the hippocampus were calculated quantitatively on both hippocampal regions of patients children and either side of control group,then compared among the lesion group,the contralateral group and control group.Expolre the relationship between the hippocampus shrink and the seizure frequency etc.ResultsThe mean concentration of NAA/Cr was significantly decreased in the focus side(1.47±0.24) compared with the nonfocus side(1.79±0.35) and the controls (1.81±0.27),but nonsignificantly between the nonfocus side and controls.Moreover, the mean hippocampal volume of focus side of patients(2.75±0.35cm~3) was significantly reduced compared with that of nonfocus side(3.06±0.46cm~3) and the controls(3.11±0.17cm~3),reference ranges of NAA/Cr and hippocampal volume in control group as standard.Furthermore,seizure frequency was no relation to hippocarnpus volume shrink in TLE children.The degree of hippocampus volume reduction was not related with the seizure frequency,but the history of febrile convulsions had significant influence to the hippocampus.Conclusions3.0T ~1H-MRS and vMRI could be useful for localization in the region of hippocampal lesions,and quantify biochemical metabolic disorders and morphological changes.They could be complementary modality to provide the reliable information for diagnosis and treatment in fTLE children.
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