The Clinical Research In The Treatment Of Qing Li Huo Xue(QLHX)-Concoction To Chronic Cholestatic Hepatitis(Stagnation Heat Type)

Objective:To observe the clinical efficacy and adverse reactions of Qing Li Huo Xue(QLHX)- Concoction to Chronic Cholestatic Hepatitis, and evaluate objectively the treatment of Chronic Cholestatic Hepatitis efficacy and safety,and explore an economic safety, efficacy reliable,promote appropriate treatment of cholestatic hepatitis beneath the effective prescription.Methods:The qualifild test-acceports case from the department of Hepatitis of traditional Chinese medicine hospital of Hubei.Sixty cases were randomly divided into 2 groups,each 30, one for treatment and the other for control,observed by double blind method.The treatment group took the traditional Chinese herb medicine QLHX,one doseaday.The control group took Baoyin capsule 3 Pains three times a day.The course of treatment of the two groups was two months.Compared the levels of TBil/ALP/ALT/GGT and the changes of clinical syndrome Physical sign.Security tests include blood-routine urine-routine stool-routine kidney function and ECG.Results:1.The Clinical cure rate of the treatment group was 23.3%, and its total effective rate was 83.4%.The Clinical cure rate of the controlled group was 16.7%,and its total effective rate was 70%.Effect of the treatment group than the control group between the two groups was significant difference(P＜0.05).2.Two of the main clinical symptoms compared total score was significantly higher(P＜0.01) between the two groups was significant(P＜0.05),indicating the two groups can effectively improve the clinical symptoms and signs,in the treatment group improved two threatening pain,skin 1tehing,swelling,weakness, lack of appetite and other symptoms and signs better than the control group.3.Two groups of Patients before treatment of STB,GGT,ALT, ALP levels increased significantly and obviously reduced after treatment,there was a significant difference before and after treatment(P＜0.05).After the treatment groups TBil,GGT,ALT,ALP level compared with the control group was significant(P＜0.05).4.During the clinical trial,no adverse reactions were observed.Follow-up results suggest QLHX concoction of a more stable long-term results.5.Statistical analysis:After the test was over statistical analysis,P(0.05) was considered to be statistically significant.Conclusion:QLHX—Decoction could significantly improve the chronic cholestatic hepatitis patients with clinical signs and symptoms, can significantly improve the quality of life and more effective than Baoyin unit.Clinical trials not occurring more serious adverse events that QLHX-Decoction is an effective,safe treatment of chronic cholestatic hepatitis medicine formulations.